398 S. SAGUCHI 



broken down into irregular clumps or granules and disappears 

 (figs. 119, 120). 



From these observations and those which I have made in the 

 study of the epidermal glandular cells of Amphibia, the con- 

 clusion is warranted that the physiological degeneration of 

 these cells is characterized by nuclear and nucleolar hyper- 

 chromasy and by chromatic separation, succeeded by the con- 

 striction of the nucleus and the cell-body; and, secondly, that 

 the formed fragments are invariably taken up by the neighbor- 

 ing normal glandular cells, but are never eliminated into the 

 lumen nor, which appears very strange, absorbed by the 

 phagocytes. 



That the pancreatic cell undergoes physiological degenera- 

 tion, has already been noticed by Gaule ('80) and Nussbaum 

 ('82) ; Platner ('89), however, was the first to describe the nuclear 

 changes brought about by that process. The author has found 

 pictures corresponding to one which is designated by Flemming 

 as 'chromatolysis' in the pancreas of various species. In con- 

 sequence of the chromatolysis, there are produced smaller or 

 larger spherical corpuscles, which at first stain with safranin a 

 red color, but later refuse to take the stain. The structures are 

 delineated in his figures 11 to 13. Of these, the large corpuscle 

 in the cell a, figure 12, corresponds to a nucleus which has already 

 undergone chromatic separation, while those seen in the cells, 

 figure 12, b, figures 11 and 13 cannot be interpreted as anything 

 else than fragments constricted off. In addition to these, 

 Platner found such corpuscles in the normal cell with an intact 

 nucleus, and assumed that they are produced by the partial 

 chromatolysis of the nucleus. In my opinion, these corpuscles 

 are in all probability fragments taken up by the normal cell, as 

 is clear from a comparison of his figures 11 to 13 and those of 

 my own (figs. 114, 118). Furthermore, he does not express 

 himself regarding the process of his partial chromatolysis. 

 Melissinos and Nicolaides ('90), Macallum ('91), and Gamier 

 ('00) also describe the occurrence of karyolysis in the pancreas. 

 According to Macallum, the product of karyolysis and cytolysis 

 consists partly of protoplasm, partly of eosinophile substance; 



