GLANDULAR CELLS OF THE FROG'S PANCREAS 405 



separation, so that the condensed chromatin is accumulated in 

 the periphery while the nuclear sap and the nucleolus are en- 

 closed by this chromatic capsule. On the other hand, Platner's 

 figure 12 and Ogata's figure 7, a, correspond to the glandular 

 cells containing these changed nuclei. Ogata's figure 7, a, es- 

 pecially shows an elongated cell, which perhaps will be frag- 

 mented in the next stage. 



Secondly, Ogata's figure 5, b, c, d, Platner's figures 11 and 13, 

 Melissinos and Nicolaides' figures 9 to 15, Eberth and Miiller's 

 figure 16, Ver Eecke's figures 17 to 24, and Babkin, Rubaschkin 

 and Ssawitsch's figure 10 (the cell to the left) show cells which 

 contain spherical bodies with either ring- or crescent-shaped, 

 larger or smaller spherical chromatic corpuscles; these bodies 

 are to be regarded as constricted off fragments of degenerated 

 cells, which have been taken up by the normal glandular cells; 

 the chromatic corpuscles correspond to nuclear fragments. On 

 the other hand, there can be seen in Ogata's figure 6, b, and in 

 Babkin, Rubaschkin and Ssawitsch's figure 10 (the cell to the 

 right), seventeen bodies which contain no chromatic corpuscles, 

 and which are, in all probability, cytoplasmic fragments with or 

 without zymogen granules. 



Finally, Ogata's figure 3, a, b, Galeotti's figures 28 and 29, 

 Garnier's figures 34 and 35, etc., show that spherical, ring or 

 crescent-shaped chromatic corpuscles are contained in the nor- 

 mal glandular cells; they are regarded by these authors as 

 nucleoli passed out of the nucleus. In my opinion, they are 

 nuclear fragments with a very small amount of the cytoplasmic 

 portion, which have been reduced in size by repeated fragmenta- 

 tion. These chromatic corpuscles gradually grow pale and then 

 stain only with plasma dyes. Under these circumstances, it is a 

 difficult matter to decide whether the spherical corpuscles stained 

 by plasma dyes are derived from the fragments with or without 

 nuclear portions. 



It is evident from the above comparison that the spherical 

 corpuscles which have been regarded as belonging to the so-called 

 'nebenkern' are the same as the fragments produced by the 

 fragmentation of the degenerated glandular cell. That the sig- 



