120 DELLA DRIPS 
the luteal cells. In Cohn’s paper previously mentioned, he 
describes some granules which he thinks may be the same as 
those described by Regaud and Policard. He also gives his 
reasons for believing that the fatty osmic-stained droplets, 
seen in the luteal cells in greatest abundance when the cells 
reach their maximum hypertrophy, are real secretion droplets 
and not evidences of fatty degeneration as had been previously 
contended. 
Along with the attempt to discover by a special histologic 
technic, evidences of secretory products in the luteal cells, a 
number of men sought to discover, by animal experimentation, 
proofs of the glandular action of the corpus luteum. The uterus 
and the mammary glands, in the minds of all, were the most 
closely associated of all the organs of the body, with the ovaries. 
Ovulation had been observed to be closely related to menstrua- 
tion in the human and to the heat periods in animals. Complete 
double ovariectomy was known to stop. menstruation, cause an 
atrophy of the uterus, and, in young women, to bring on meno- 
pause symptoms. In the very young castration had prevented 
the development of the uterus and mammary glands. Double 
ovariectomy in pregnant women, especially in the first months, 
was known to be followed by abortion. 
Various attempts had been made to overcome the bad effects 
of ovariectomy by the transplantation of ovaries and by ovarian 
medication. These were reported to have given good results, 
at least partially. 
All these facts seemed to speak for the production of an 
internal secretion in the ovaries which affected the uterus and 
mammary glands. 
Fraenkel (’06) was the first to attempt to prove by a series of 
experimental studies on rabbits and cats that the corpora lutea 
in the ovaries were responsible for the various effects produced 
on these organs. 
He begins his papers as follows: ‘‘The corpus luteum must, 
from its structure and development, be a gland of internal 
secretion, made to insure the implanting and development of 
the fertilized egg in the uterus. The corpus luteum maintains 
