122 - DELLA DRIPS 
coitus only will bring about ovulation. The congestive phenom- 
ena which they notice in the ovaries during rut will not produce 
the rupture of a single follicle without coitus. 
Niskoubina, the same year (’09), published a series of studies 
which confirmed the observations of Ancel and Bouin. He first 
made a histologic study of a series of ovaries removed at varying 
intervals after coitus and then did some experiments similar to 
Fraenkel’s to determine the period during which the ovaries 
seem to exert an influence on the pregnant uterus. From his 
experimental studies, he concludes: ‘‘The corpus luteum exer- 
cises an obvious action on the physiology of pregancy. It puts 
the uterus in a condition necessary to assume the development 
of the fertilized egg. This action lasts during the first half of 
pregnancy, after which it ceases to act.” 
Loeb (’08) published a paper in which he states that deciduo- 
mata can be produced experimentally in the uterine mucosa of 
guinea-pigs by making a number of transverse and longitudinal 
cuts so as to break the continuity of the tissue. He states that 
this can happen only during a certain definite period after 
copulation, between the fourth and the eighth days. This is 
the time when freshly formed corpora lutea are present in the 
ovaries. These changes were not excited by the presence of 
ova, since they took place when the uterus was ligated and the 
passage of ova prevented. If the ovaries were removed, de- 
ciduomata could not be produced. He concluded, then, that 
the ovaries at certain periods after ovulation elaborate a pre- 
disposing substance, in the presence of which indifferent stimuli 
may produce deciduomata. 
Parhon, Dumitresco and Nissipesco (’09) published a paper 
on the lipoids of the ovary. From various staining reactions 
on sections of ovaries and from chemical reactions of a powder 
made from ovaries, they conclude that in the interstitial cells 
of the ovary and in those of the yellow body fats are found which 
differ in many characteristics from the fat of the adipose tissue. 
Mulon (’10) reported that the fat in the corpus luteum, which 
stains only faintly with osmic acid, was similar to other fats 
found in the adrenal and other organs of the body which form a 
