124 DELLA DRIPS 
He says: ‘‘Far be it from our idea of admitting two abso- 
lutely distinct phases for serous secretion and lipoid secretion. 
On the contrary, at a moment in the development of the corpus 
luteum these two processes coexist, but the first is especially 
marked at the beginning of gestation and the second exists alone 
during the following period.’”’ He concludes that: ‘‘the serous 
secretion exercises its influence on the transformations of the 
uterine mucosa of the first phase of gestation during the dis- 
placement of the egg and that the lipoid secretion intervenes 
principally to provoke the arrest and fixation of the blastocyst 
and the formation of the placenta.” Van der Stricht has not 
been able to demonstrate this serous secretion in the luteal cells, 
but because it is present in the central cavity of the young corpus 
luteum and in the lymphatics when they are first formed, he 
thinks the cells must be secreting it. Both the serous secretion 
and the lipoid secretion are carried away, he says, by the 
lymphatics. 
Corner (’16) published a paper on the corpus luteum of preg- 
nancy in swine. He claims to have found in the corpora lutea 
of pregnancy, beside the cells which are descendants of the 
granulosa cells and the cells which are descendants of the theca 
cells, two more types of cells which can be found at all stages of 
pregnancy. 
Livon (’09) published the results of the effect of injecting 
luteal extract into guinea-pigs. He writes as follows: “We have 
employed an extract of the corpora lutea of the sow and the 
cow, a product that I have today called the Product A. In- 
jected into the peritoneal cavity of guinea-pigs, we find a toxic 
action varying with the rapidity of the absorption and with the 
individual. The toxic.dose obtained generally is 20 to 30 centi- 
grams per kilogram of animal. The animals die presenting 
general tremors,dyspnea, convulsions and uttering weak cries.”’ 
Champy and Gley (11) are said to have been the first to show 
that the corpus luteum from pregnant cows was exceedingly 
active, whereas that from non-pregnant animals possessed little 
physiologic action. 
Hare (712) reported very favorably on the clinical use of 
corpus luteum extract. 
