150 DELLA DRIPS 
Gross and microscopic observations. Some slight differences can be 
noted between the uteri of spermophiles 374 and 378 and their control. 
The uteri of the doubly ovariectomized spermophiles are both smaller 
than their control. This decrease in size is more noticeable in the 
cervix than in the rest of the uterus. The cervices of these two uteri 
are much firmer also and contain very little mucus. It is true, the 
differences are only slight and are scarcely recognizable microscop- 
ically, especially after fixation. The main microscopic difference is a 
decrease in size of the blood-vessels in the uteri of the ovariectomized 
spermophiles. Perhaps this accounts for the fact that the uterus of 
the control has a healthier appearance grossly. 
Discussion and summary of results. The uteri of animals 
doubly ovariectomized in the spring of the year show some 
changes over their controls by the fall of the same year. These 
are slight and are all of the nature of a functional atrophy. The 
cervix is affected the most. This atrophy increases so as to be 
quite noticeable by the fall of the next year. The very striking 
effect of double ovariectomy is the discontinuation of the changes 
in the uterus incident to the phenomena of rut. 
Series 4. Effects of removal of both ovaries on the pregnant uterus 
Experiment 293-16 (spermophile 328). Captured May 4, 1916. 
Weight, 119 grams. Operated on May 6, 1916. Both ovaries were 
removed. 
Gross observations. The animal is in an early stage of pregnancy, 
the placental swellings being just visible grossly in the uterus. 
Sacrificed May 20, 1916. Weight, 115 grams. 
Gross observations. There are no signs of placental sites in the 
uterus. To be sure the animal had been pregnant, the ovaries were 
studied carefully. They contained early corpora lutea. Evidently 
the regression changes began in. the uterus immediately after the re- 
moval of the ovaries. 
Experiment 300-16 (spermophile 335). Captured in the spring of 
1916. Weight,101 grams. Operated on May 8,1916. Both ovaries 
were removed. 
Gross observations. The animal was in an early stage of pregnancy, 
the placental swellings being just large enough to be recognizable. 
Died May 12, 1916. 
Gross observations. The external wound is in bad condition, per- 
haps the fault of too much iodin. The inside of the abdominal cavity 
appears normal. The uterus is in good condition save on the ends 
where the blood supply has been injured. The congestion is much 
reduced. There are placental swellings, hard and dark red; five in 
the right horn and three in the left, very hard to see. The placentas 
and fetuses are apparently undergoing degeneration. 
