SUPRARENAL GLAND—EFFECTS OF INANITION 231 
forms but a small part of the gland. It usually appears rela- 
tively large in the new-born, however, decreasing later in relative 
size on account of more rapid growth in the cortex. In the rat, 
although the suprarenal becomes relatively larger in the female, 
there is apparently no constant sexual difference in the relative 
size of cortex and medulla. The whole question of the changes 
in relative size of cortex and medulla according to age and sex in 
various species deserves a more careful and extensive study. 
2. In young rats stunted by underfeeding 
As previously shown (Jackson, 715 b), in young-rats held at 
maintenance (nearly constant body weight) by underfeeding for 
various periods there is a definite tendency to increase in the 
weight of the suprarenal gland, especially in the female. The 
observations in table 2 B indicate no marked change in the rela- 
tive volumes of the cortex and medulla as a result of such experi-. 
ments, however. While during normal growth up to ten weeks 
the suprarenal medulla tends to lag behind (cortex becoming 
relatively larger), in the maintenance experiments it apparently 
remains nearly constant in relative size. Lewis and Pappen- 
heimer (716) likewise found no constant change in the relative 
size of cortex and medulla in the suprarenal glands of children 
emaciated through malnutrition. 
3. In rats refed after stunting 
As shown by table 2 B, in rats refed one or two weeks (after 
being held at maintenance from three to twelve weeks of age), 
the relative sizes of the suprarenal cortex and medulla appear 
nearly normal. Ina permanently stunted female (St 33.120, re- 
fed to one year after maintenance from three to twenty-one weeks 
of age), the medulla appears relatively large, while in a male 
(S 33.118) similarly refed the ratio appears nearly normal. Stew- 
art (16) found that in rats refed four weeks or less, after main- 
tenance from three to twelve weeks of age, the suprarenals 
seem to lag behind somewhat in weight, although they appeared 
normal in such rats refed to the age of one year. 
