SUPRARENAL GLAND—EFFECTS OF INANITION 233 
In adult rats subjected to either acute or chronic inanition, 
there appears to be an increased vascularity of the middle and 
inner cortical zones, with a decreased vascularity in the medulla. 
Marked hyperemia of the suprarenal cortex has also been noted 
as a result of inanition in the guinea-pig (Martinotti, ’92; Ron- 
doni and Montagnani, ’15). 
The most constant effect of inanition upon the suprarenal 
stroma is therefore an increased hyperemia of the inner cortical 
zone. The changes in the vaseularity of the remainder of the 
gland appear variable in different individuals and according to 
the type of inanition. The variations are due chiefly to the 
amount of blood remaining in the vessels, which of course may 
vary greatly under different circumstances. Moreover, the 
amount retained in the vessels after death may be quite different 
from that during life. In pathological histology, however, it is 
customary to judge as to relative anemia or hyperemia by the 
distention of the vessels in prepared sections of organs. So an 
attempt to measure the amount appears justified, even though 
the results are only roughly approximate. 
SIZE OF PARENCHYMA CELLS AND NUCLEI 
The average sizes of the parenchyma cells and nuclei were not 
determined by direct measurement, but were calculated by the 
method previously explained. The data are given in table 4. 
The cell and nuclear dimensions will be considered, 1) in normal 
postnatal development; 2) in young rats stunted by underfeeding; 
3) in such rats refed after stunting, and 4) in adult rats with acute 
or chronic inanition. 
1. During normal postnatal development 
As noted by Canalis (’87) in the rabbit, there is in the rat a 
general increase in the size of the cells from birth to maturity 
(table 4). In average diameter, the cells of the outer cortical 
zone (zona glomerulosa) increase gradually from about 7 uw at 
birth to about 8 yw at three weeks and to about 9 uw from ten 
weeks on. 
