238 Cc. M. JACKSON 
4. In adult acute inanition 
As shown by table 4, a comparison of the average data from the 
four adults with those of the normal adult indicates that the 
cells of the outer cortical zone have decreased little or none in 
diameter. The middle-zone cells, however, have decreased in di- 
ameter very markedly—from 14.8 » (normal) to 12 yin the outer 
part of the zone, and from about 11.5 » to 9.2 » in the inner part 
of the zone. The inner zone cells have decreased but slightly— 
from 8.7 uw to 8.5 u. The medulla parenchyma cells have de- 
creased markedly—from 15.9 u to 12.7 » in average diameter. 
The nuclei of the outer zone indicate no shrinkage, but rather 
an insignificant increase in average diameter from 5.5 uv to 5.8 yu, 
with a corresponding slight increase in relative volume (from 
23.2 per cent to 27.1 per cent of the average cell volume). The 
middle-zone nuclei have decreased slightly in diameter (6.9 yu 
to 6.5 w in the outer part and 6.4 » to 5.5 w in the inner part 
of the zone). But since the loss in cytoplasm is greater, the 
relative nuclear volume has increased—from 10.1 per cent to 
16.2 per cent in the outer part and from 15.5 per cent to 21.7 
per cent the inner part of the zone. The inner-zone nuclei 
remain nearly constant in size and relative volume. The 
medulla nuclei appear slightly decreased in average diameter 
(7.3 » to 7.0 uw). But on account of greater loss in the cyto- 
plasm, the relative size of the nuclei has increased from 9.6 
per cent to 16.8 per cent of the cell volume. 
Barbéra and Bicci (’00), in rabbits starved seven days with 
‘oss o° 34 per cent in body weight, found the nuclei in the su- 
prarenal cortex to decrease from an average diameter of 7.238 yu 
to 4.817 y, and in the suprarenal medulla from 7.773 y» to 5.587 yu. 
The loss in cytoplasm appeared relatively greater than in the 
nucleus. Similar results were obtained in dogs. These de- 
creases in cell dimensions would appear to be much greater 
than those observed by me in the rat. Traina (’04) noted a 
decrease in the size of cortical cells in the suprarenal of the 
rabbit during starvation, but gives no exact data. 
