SUPRARENAL GLAND—EFFECTS OF INANITION 239 
5. In adult chronic tnanition 
The data from the two individuals (table 4) indicate that the 
suprarenal cells of the outer and middle cortical zones have 
lost in diameter somewhat more than during acute inanition; 
the inner zone and medulla cells about the same as during acute 
inanition (or slightly less). 
The nuclei in all the regions during chronic inanition have 
apparently lost in average diameter somewhat more than dur- 
ing acute inanition. The relative (percentage) volume of the 
nucleus is therefore usually lower than during acute inanition. 
In the outer zone and the medulla, the nucleus-plasma ratio 
is not greatly different from that of the normal animal. 
CELL DIVISION—FREQUENCY OF MITOSIS 
No conclusive evidence of amitosis was found in any of the 
suprarenal glands studied, although irregular or bilobed nuclei, 
which might easily be so interpreted, were occasionally observed 
in the various zones of the cortex and medulla. If amitosis 
occurs at all (in the rat), it is probably a degenerative phenom- 
enon of no especial significance or importance in the normal 
development of the gland. 
The frequency of mitosis in the suprarenal, under normal and 
abnormal conditions at various ages, is given in table 5. The 
average number of mitoses counted in entire sections through 
the center of the gland is shown for the various zones in the 
rats grouped according to age or condition. 
1. Mitosis during normal development 
As shown in table 5 A, the average number of mitoses in an 
entire section of the suprarenal is somewhat variable in in- 
dividual cases, but the general trend according to age is evident. 
The average number per section at birth is 20, decreasing to 
an average of 10 at one week, and increasing again during the 
second and third weeks. At twelve days (one case only) there 
were 40 mitoses per section, which was the maximum number 
