SUPRARENAL GLAND—EFFECTS OF INANITION . 243 
and Zimmerman (’12), and others. Gottschau (’83) considered 
the germinative zone to lie between the zona glomerulosa and 
the zona fasciculata, while Wiesel (’01) (in the fetal pig) and 
Da Costa (13) placed it in the middle zone (fasciculata), and 
Dsershinsay (cited by Da Costa, 713) even in the inner zone. 
Graham (’16) found that after toxic lesions regeneration of the 
suprarenal cortex proceeds from the zona glomerulosa and outer 
part of thefasciculata. In the child, mitoses may occur through- 
out the cortex. 
2. Mitosis during inanition and refeeding 
From the data given in table 5 B it is evident that the effect 
of underfeeding in young rats held at maintenance (nearly 
constant body weight) is in general to diminish very greatly 
the number of mitoses, and ultimately to prevent them entirely. 
In rat St 80.9 underfed from birth to twelve days (body weight 
increased from about 5 grams to 8.9 grams), the total number 
of mitoses found in a section of the suprarenal was 4, whereas 
normally (at corresponding age or body weight) it would be 
between 10 and 20. In ten rats held at maintenance from three 
to ten weeks of age, the average number of mitoses was reduced 
- to 1, the maximun being 3, and none present in six of the ten 
cases. In three cases in which the maintenance was continued 
to the age of twelve to twenty weeks, no mitoses were found 
in the suprarenal. 
The distribution of the mitoses in the various cortical zones 
of the suprarenal in the stunted rats appears similar to that 
in the normal glands. That is, the larger number occurs in 
the outer zone and the outer part of the middle zone. None 
was noted in the inner zone and (excepting the youngest rat) 
none in the medulla. 
In the rats refed fully for one week (after maintenance from 
three to twelve weeks) mitosis in the suprarenal has recom- 
menced. ‘The rate is still below normal, however, the average 
number being only 2 per section. In rats refed two weeks, 
the number of mitoses has increased to 10 per section, which 
