SUPRARENAL GLAND—EFFECTS OF INANITION 245 
(glomerulosa), narrow and deeply stained; 2) a middle zone (zona 
fasciculata), broader, with irregular, radial columns, and 3) an 
inner zone (zona reticularis), less distinct an more irregular, 
and (in the new-born) intermingled with the medulla. The 
medulla, which at birth is not clearly differentiated and sepa- 
rated from the cortex, is more vascular. It is composed of 
irregular cell groups or cell cords and contains a few scattered, 
deeply stained cell masses. Similar masses also appear occa- 
sionally in the cortex, especially in the region of the hilus. 
Under higher magnification, the outer cortical zone appears 
narrow, but variable in width, about six to ten cells deep. The 
cells are somewhat variable in size and structure. The cyto- 
plasm is scanty, more or less granular, and presents a few fine 
vacuoles (lipoids.) The nuclei are spherical or ellipsoidal in form, 
somewhat deeply chromatic and (as previously shown) present 
frequent mitoses. 
The middle-zone cells are larger. The cytoplasm is more 
abundant, with distinct eosinophile granules and a few (vari- 
able number) of lipoidal vacuoles, somewhat more prominent 
in cells toward the middle of the zone. The nuclei are spheri- 
cal and larger than those of the outer zone. They are less deeply 
chromatic, through occasionally pycnotic. 
The inner-zone cells resemble those of the adjacent part of 
the middle zone, with distinctly granular cytoplasm and a few 
fine vacuoles. Many of the cells are degenerative in appear- 
ance, with indistinct cytoplasm and karyolytic or pycnotic 
nuclei, sometimes fragmented (karyorrhexis). The inner zone 
cells of the cortex extend into the medulla, and are intermingled 
closely with groups of the medulla cells, from which they are 
frequently difficult to distinguish (in the usual preparations). 
Inaba (91) likewise found an intermingling of cortex and medulla 
in the new-born mouse. 
The medulla cells of the suprarenal in the rat are polymorphic, 
in irregular cords and clumps, separated by relatively large 
blood sinuses. The cytoplasm is very scanty and the cell 
boundaries are usually indistinguishable (as also in the cortex). 
The cytoplasmic (chromaffin?) granules usually appear baso- 
