SUPRARENAL GLAND—EFFECTS OF INANITION 249 
Under higher magnification the cortical zone cells appear in 
general similar to those of the new-born. The inner-zone cells, 
however, no longer intermingle with those of the medulla, but 
(aside from a few scattered islands of cortical cells) present a 
fairly even and very distinct line of demarcation. Next to 
this border, the cortical cells frequently appear flattened and 
more or less atrophic, probably due chiefly to absorption by 
the expanding medulla. 
The medulla has become confluent as a central mass, which 
may also reach the surface at the hilus (compare fig. 10). It 
has undergone a marked change in structure and appearance. 
The stroma is well differentiated, forming an irregular syncytial 
net work containing elongated nuclei and fine fibrillae. The 
parenchyma cells are likewise syncytial. The cytoplasm is 
more abundant and presents small vacuolated (non-lipoidal) 
spaces, variable in size and number. ‘The fine violet cytoplasmic 
granules are present, but variable and usually scanty. The 
nuclei are somewhat variable in form, but usually spheroidal 
and vesicular, very slightly chromatic. Some are smaller and 
more deeply staining, occasionally even pycnotic. Bilobed 
dumb-bell-shaped nuclei are occasionally seen in the medulla 
(as also in the cortex), but these are comparatively rare. It 
is doubtful whether they are to be considered as evidence of 
amitotie cell division. The deeply staining masses (sympatho- 
chromaffin cells) mentioned in the new-born occur rarely in 
the suprarenal medulla at one week. 
In a rat at eight days (F 11.3) frozen sections unstained or 
stained with scarlet red or osmic acid show the liposomes some- 
Fig. 1 Longitudinal section of the suprarenal gland of a new-born albino 
rat (F 8.1). Formalin fixation; frozen section stained with Herxheimer’s scarlet 
red. Liposomes visible in the cortex and in the cortical strands throughout the 
medulla. The light band, relatively lipoid-free, which separates the outer and 
middle cortical zones is already evident. X 80. 
Fig. 2. Longitudinal section of the suprarenal gland in an albino rat three 
days old (F 11.1). Formalin fixation; frozen section stained with Herxheimer’s 
scarlet red. The medulla is confluent, and the intermixed cortical strands are 
undergoing absorption, with the establishment of a definite corticomedullary 
boundary. X 80. 
