SUPRARENAL GLAND—EFFECTS OF INANITION Pas w | 
what similar to those of the first week. Those of the outer 
zone are relatively most abundant, varying from fine to coarse, 
the largest approaching nuclear size. The subjacent narrow 
light band is relatively free from lipoids, with only a few fine 
granules. In the middle zone the liposomes are less uniformly 
distributed than heretofore, becoming more abundant in the 
outer half of the zone. They are less abundant in the inner 
zone. Here occur a few coarsely granular cells, which also 
appear as individual cells or small groups sparsely scattered 
through the medulla. These islands represent unabsorbed 
remnants of the earlier cortical strands. 
The chromaffin reaction of the medulla, though distinct, is 
still comparatively weak, as during the first week. 
At ten to fourteen days, the suprarenal in general structure 
and appearance, in sections stained with hematoxylin-eosin, is 
similar to that at one week. Lipoidal vacuoles are becoming 
more abundant in the outer and especially the middle cortical 
zone. The reddish (eosinophile) cytoplasmic granules of the 
cortical cells are in contrast with the pale violet (faintly baso- 
phile) granules of the medulla cells. The cortical cells of the 
inner zone are usually normal in appearance, but frequently 
atrophic and degenerated, especially in certain areas. Large 
sympathetic ganglion cells appear in the medulla. 
Fig. 3 Portion of a section of the suprarenal gland in a normal adult albino 
rat (F 3.1). Formalin fixation; frozen section stained with Herxheimer’s scarlet 
red. Liposomes most abundant in the outer cortical zone and the outer half of 
the middle zone. fF, fibrous capsule, with ordinary fat droplets in the tissue 
outside; O, outer zone (glomerulosa); 7’, transition band, relatively lipoid-free; 
Mo, outer part of middle zone (fasciculata); Mz, inner part of middle zone; J, 
inner zone (reticularis); 7, medulla. > 90. 
Fig. 4 Portion of a section of the suprarenal gland of an adult albino rat 
(F 3.2), after nine days of acute inanition. Formalin fixation; frozen section 
stained with Herxheimer’s scarlet red. For explanations, see figure 3. No 
apparent decrease in the liposomes, which appear more uniformly distributed 
throughout the cortex. The light band at the transition between outer and 
middle zones is obscured. X 90. 
Fig. 5 Portion of a section of the suprarenal gland of an adult albino rat 
(F 4.2) after twelve days of acute inanition. Formalin fixation; frozen section 
stained with Herxheimer’s scarlet red. The liposomes persist in the outer zone 
(O), but have nearly all disappeared elsewhere. A few are barely visible in the 
outer half of the middle zone (Mo), and in the inner zone (J). X 90. 
