SUPRARENAL GLAND—EFFECTS OF INANITION 259 
Weerzynowski,’10) ; and in the sheep, according to Mayer, André, 
Mulon and Schaeffer (’12), the sparse lipoidal granules are lo- 
cated exclusively in the outer zone. The characteristic fat-free 
band between the zona glomerulosa and the fasciculata was 
noted in the rat by Bonnamour (’05 b). Babes and Joneseo (’08) 
likewise noted a scarcity in fat between these zones in the dog, 
but Mulon (712), on the contrary, finds larger droplets at this 
level. The composition of the suprarenal liposomes is generally 
considered to be chiefly lecithin or cholesterin with a variable 
admixture of ordinary fats (compare Ciaccio, 710, and Kawa- 
mura, 711). 
Pigment has often been described in the inner cortical zone of 
the guinea-pig (even in the albino, according to Mulon) and man, 
but less frequently in other forms. It was noted by Gottschau 
(83) and Pfaundler (92) in most mammals, Baroncini and 
Beretta (’01) in bats, and by Elliott and Tuckett (’06) sparsely 
in the duckbill and pigeon. Bonnamour (’05 a) found it variable 
in the dog and horse, and absent in the cat, rabbit, and marmot. 
He found it rarely inthe rat, with no difference in pigment be- 
tween white and black rats. DaCosta (713) also noted a few 
pigment cells in the zona reticularis of Mus decumanus. Dewit- 
ky (12) likewise noted brownish pigment in the cortex of the 
rat at seven weeks. - Delamere (’03) and others have noted that 
the amount of pigment usually increases with age, being rare or 
absent in the young. Mulon (’02, ’03 a), Ciaccio (’05), Kolmer 
(712 b), and others believe that the pigment formation may rep- 
resent a secretion with physiological significance, and an in- 
crease during pregnancy (guinea-pig) is claimed by Kolmer (12 a). 
As to its composition, this pigment has usually been considered 
as related to fat (lipochrome), although Starkel and Wegrzynow- 
ski (710) and Thomas (’11) consider that the pigment appearing 
in the degenerating inner cortical zone of the suprarenal in the 
human new-born is of hemal origin and different from the pig- 
ment in the adult gland. 
The suprarenal medulla in the rat at ten weeks and older may 
extend to the surface at the hilus (fig. 10), as found by Poll 
(99). It is similar in structure to that described in earlier stages. 
