SUPRARENAL GLAND—EFFECTS OF INANITION 263 
tioned and stained as usual. In general, the nuclei appear more 
hyperchromatic, though not much more than in the normal 
gland at three weeks. Although the fat in the fibrous capsule 
around the gland has apparently almost entirely disappeared, 
the lipoidal vacuoles of the outer zone of the cortex are abundant. 
In the middle zone, however, they are apparently not more num- 
erous than in the normal at three weeks. In the inner part of 
the middle zone many cells are degenerating some in various 
stages of disintegration. The atrophic degeneration and pig- 
ment formation in the inner cortical zone is very marked. The 
greenish-yellow, vacuolated pigment masses in many cases have 
entirely filled the cells and are quite numerous. The medulla 
cells show increased vacuolization, sparser granulation, and hy- 
perchromatic (frequently pyenotic, some karyolytic) nuclei. In 
general, however, the structure is less changed than in the cortex. 
3. Changes in young rats refed after stunting by underfeeding 
In the rats refed fully after maintenance from three to twelve 
weeks of age, the suprarenal gland rapidly returns to approxi- 
mately normal structure. Even after one week of refeeding the 
cortex appears distinctly lighter in stained sections, due to a de- 
crease in the chromatin content of the nuclei. The lipoids ac- 
cumulate more abundantly (especially in the outer half of the 
middle zone) and the inner cortical zone becomes somewhat less 
atrophic in appearance. By the end of two weeks of refeeding, 
the gland has reached nearly normal structure, although some 
areas of degeneration may persist for longer periods. Even those 
held at maintenance up to twenty weeks of age (S 33.118 and $ 
33.120), with permanently stunted body weight, show practi- 
cally normal structure in the suprarenals after being refed fully up 
to about one year of age. 
4. Changes in adult rats after acute or chronic inanition 
Adult acute inanition. Adult rats were given water only for 
seven to twelve days, with loss in body weight of 29 to 45 per 
cent (table 1 D). The suprarenal glands, as previously shown 
