264. Cc. M. JACKSON 
(Jackson, 715 a), lose but little in absolute weight during adult 
inanition. The cells (especially those of the middle cortical zone 
and the medulla) during acute inanition apparently diminish in 
size, however, as shown in table 4. The decrease in cell size is 
counterbalanced by hyperemia of the cortex, though apparently 
the reverse (decrease in proportion of vascular stroma) occurs in 
the medulla. 
Sections of the suprarenal, stained with hematoxylin-eosin, 
show changes in histological structure. The cytoplasm is re- 
duced in amount and the eosinophile granules usually indistinct. 
The nuclei are variable, frequently hypochromatic. More fre- 
quently, however, they appear hyperchromatic, though less so in 
the outer half of the middle zone. Pycnosis and deformity of 
the nuclei are frequent, as described by Bonnamour (’05b) in 
the outer cortical zone of the starved rat. The lipoidal vacuoles 
are variable. Usually, however, they are absent or considerably 
reduced in number and size in the middle zone, though persisting 
nearly unchanged in the outer zone. The eosinophile granules 
of the cortical cells, though sometimes indistinct, are often well 
preserved and become more evident with the reduction in the 
amount of lipoids present. 
The inner cortical zone shows the hyperemia and atrophic con- 
dition usually more pronounced than in the normal animal. 
Pigment masses are frequent, but it is somewhat doubtful whether 
they are increased in number. Degenerating cells with pycnotic 
or karyolytic nuclei in various stages of disintegration are 
numerous. 
Scarlet red or osmic staining of fresh frozen sections reveals 
_the cortical liposomes much more abundant than would be sus- 
pected from the ordinary stained paraffin sections. In some 
cases the usual fat-free boundary line between the outer and mid- 
dle zones is nearly obliterated by an increased development of 
liposomes, and they may appear more uniformly . scattered 
through the middle zone, and even the inner zone (fig. 4). 
This tendency toward a more uniform distribution of the lipo- 
somes throughout the cortex was noted in three of the eight cases 
of adult acute inanition stained especially for lipoids, though the 
