SUPRARENAL GLAND—EFFECTS OF INANITION 265 
total amount of the lipoids appears somewhat reduced in one of 
them (F 1.2). A similar ‘Verbreitung der lipoidhaltigen Schich- 
ten’ was observed by Landau (713 b) in fasting guinea-pigs. 
In five of the eight rats in my series, however, the change con- 
sists In a very marked reduction in the liposomes of the middle 
and inner zones. Under the low power of the microscope only a 
few liposomes may remain visible in the outer half of the middle 
zone, the remainder of the middle and inner zones being appar- 
ently free from them (fig. 5). Under higher power, however, 
numerous extremely fine granules are often still visible in all these 
cortical cells. The effect in such cases is therefore apparently 
merely to reduce the liposomes very muchinsize. In other cases, 
the liposomes have entirely disappeared. The pigment cells 
near the corticomedullary zone apparently persist nearly un- 
changed, contrary to Rondoni and Montagnani (’15), who found 
a decrease in fasting guinea-pigs. 
In striking contrast with the remainder of the cortex is the 
narrow outer zone, in which the liposomes persist with great 
tenacity (fig. 5). With the scarlet stain, this zone therefore ap- 
pears nearly unchanged as a deep reddish band, while the re- 
mainder of the cortex appears pale, nearly colorless, or with a 
pale, diffuse reddish color suggesting some fat-like substance in 
solution. Osmic preparations give corresponding pictures. In 
only one case (F 9.3) the outer zone in places appears somewhat 
broken and irregular. The tenacity of the outer lipoidal zone is 
not due to any visible difference in the structure or composition 
of the liposomes in this zone. Landau (13 b), however, finds 
that in the fasting guinea-pig, although there is no decrease in 
the total lipoid content, the cholesterin decreases in all but the 
outer cortical zone. It may be dependent upon the vascular 
arrangement, as all of the blood to the cortex passes first through 
the capillaries of this zone (Flint, ’00). 
The amount of decrease in the liposomes of the suprarenal cor- 
tex is usually, but not always, somewhat proportional to the 
length of the fasting period or to the loss in body weight. In 
general, the lipoids appear much more resistant to inanition than 
does the ordinary fat just outside the suprarenal capsule. 
