AUTHORS’ ABSTRACT OF THIS PAPER ISSUED 
BY THE BIBLIOGRAPHIC SPRVICE, APRIL 19 
REACTIONS OF CELLS IN THE TAIL OF AMPHIBIAN 
LARVAE TO INJECTED CROTON OIL 
(ASEPTIC INFLAMMATION) 
ELIOT R. CLARK AND ELEANOR LINTON CLARK 
Department of Anatomy, University of Missouri 
FIFTEEN FIGURES 
INTRODUCTION 
For a number of years the authors have been engaged in a 
study of the growth and reactive power of connective-tissue 
cells, wandering cells, and of blood-vessels and lymphatic endo- 
thelium. These cells and tissues are conceded by most investi- 
gators to have a common origin ultimately in a primitive mesen- 
chyme cell, but there is no such unanimity of opinion as to the 
manner in which they differentiate, and there has been a great 
deal of controversy in regard to the degree to which they become 
specific in the adult organism. In former studies of the normal 
growth of these cells and tissues and of their reaction to injected 
substances, such as paraffin oil, carbon granules, olive oil, yolk 
of egg, etc., in the transparent tails of living Amphibian larvae, 
we found that the individual cells and tissues remained specific 
in their growth and in their response toward outside stimuli 
Ce-LR. Clark;:709;, 712.7163 H,. R.cand:K. di Clark, ’17).. The 
question of the specificity of tissues has been raised most fre- 
quently, with respect to this very group of cells and especially 
during the process of inflammation in which they play such a — 
prominent role. We therefore decided to produce a micro- 
inflammation in the transparent fin of an Amphibian larva and 
to study the reaction of these different cells and tissues toward 
an injurious agent by continuous observation of the living. 
Hyla larvae were used almost exclusively in these studies. 
These diminutive tadpoles have very few pigment cells and their 
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THE AMERICAN JOURNAL OF ANATOMY, VOL. 27, NO. 2 
