REACTION OF CELLS TO CROTON OIL 239 
aC 
A B C 
Fig. 9 Series illustrating the changes in a single connective-tissue cell situated 
near the globule of croton oil. Illustrates serious injury and complete recovery. 
A. Sketch made June 4th, 1 P.M., just before injection. B. Sketch made June 
4th, 2:45 P.M., one-half hour after injection of croton oil. Processes shortened, 
nucleus visible, vacuoles present. C. Sketch made June 4th at 4 P.M., processes 
mostly withdrawn, more vacuoles present. D. Sketch made June 6th, 2:30 
P.M. about twenty-five hours after the extrusion of the oil globule. Cell has 
recovered—processes radiate toward the site of injury. E. Sketch made June 
7th, 4 P.M., three days after the injection of croton oil and two days after the 
extrusion of the globule. Cell has completely regained its normal appearance. 
A, X200=B-E, 300. : 
Fig. 10 Series of sketches of another connective-tissue cell situated very near 
to the site of injection. Illustrates extreme grade of injury. This is one of the 
few examples observed in which the cell did not recover. A. Sketch made June 
4th, 1 P.M., before injection of croton oil. B. June 4th, 2:30 P.M., fifteen minutes 
after the injection. Processes shorter and thicker. Nucleus visible. C. Sketch 
made June 4th, 4:30 P.M. Processes withdrawn, vacuolization. D. Sketch 
made June 5th, 9:40 P.M. About ten hours after extrusion of the oil globule. 
Practically all the other connective-tissue cells of the region have recovered. 
This cell is a thin-walled sac containing vacuoles or granules. Nucleus does not 
show. On ‘the following day (June 6) this cell was still present as a shadowy 
outline containing a few granules in Brownian movement. On June 7th no trace 
of it could be found. A, 200; B, C, D, 300. 
