150 JOHN SUNDWALL 



the lachrymal sac and canal. Speciale-Cirincione ('08) states 

 that in man — ''Die Anlage der Tranendriise beginnt mit dem 

 2. Monat, zu einer Zeit, wo die Lidspalte noch weit offen steht. 

 Die Entwicklung geht alsdann sehr rasch vor sich, so dass von 

 einem Tage zum anderen eine erhebliche Aenderung zu bemerken 

 ist." 



The innervation of the lachrymal gland has been studied by 

 Dogiel ('93), Jendrassik ('94), Tepliachine ('94), Laffaye ('97), 

 W. Klapp ('97), P. Klapp ('97), Landolt ('00), Puglisi-Allegra 

 ('03) ('04), and Schirmer ('04). The works of Dogiel and 

 Puglisi-Allegra are of particular interest here as the others are 

 chiefly contributions from a chnical standpoint. 



Dogiel used the methylene-blue and Golgi's methods on the 

 lachrymal glands of the guinea pig and rabbit. According to 

 him ''Die Thranendriise empfangt fast ausschlieslich marklose 

 Nervenfasern, solche, die Blutgefasse und die Ausfiihrungsgange 

 umflechtend, . . . und bilden ein Geflecht in dem auf der 

 memb. Propria derselben sich lagern." A peritubular and 

 intercellular net work of these fibers is described. 



Puglisi-Allegra ('03), using Golgi's method and the vital 

 staining with methylene-blue, describes peritubular, intraperi- 

 cellular, intracellular fibres, and sympathetic ganglia cells situ- 

 ated on the course of the sympathetic fibres. 



Schirmer describes both medulated and nonmedulated nerve 

 fibres in this gland. 



Clinical observations seem to favor the view that the secre- 

 tory fibres are derived from the facial nerve through the Nervus 

 petrosus superficialis major by way of the Ganglion Spheno- 

 palatinum (Klapp). 



The vascular supply and lymphatics have been studied by 

 Puglisi-Allegra ('04). 



The position and gross characteristics of the gland have been 

 described by Ellenberger ('06) and by Ellenberger and Baum 

 ('08). 



Regarding the finer structures of the gland there have been 

 many contributions. Not all are agreed, however, as to the 

 form of the secreting elements (whether tubules or alveoli). 



