228 JOHN SUNDWALL 



8. The cells constituting the tubules or acini present different 

 pictures depending upon the secretory stage they are in. In the 

 maximum granular stage the cells are large spherical or oval 

 (bulging), the granules fill the entire cell and the nucleus is 

 flattened against the base. When the secreting cavity is made 

 up of these cells it may have the form of an alveolus or acinus. 

 Cells in a medium or minimum granular stage are cylindrical, 

 pyramidal, hour-glass shaped, or may appear as crescents. As 

 a rule they are seen compressed between the large bulging cells 

 in each tubule. They are frequently seen, however, making 

 up the entire secreting cavity. These cells are much reduced 

 in size when compared with the former. Granules may fill the 

 entire cell or only few may be present. Occasionally these cells 

 show no granules. The nucleus is round or oval and is always 

 separated from the base of the cell by a zone of cytoplasm. 



9. The cells of the intercalary duct do not show such dis- 

 turbances. Whether these cells are in a maximum or minimum 

 granular stage, the size and shape remain practically the same. 

 Xo changes are seen in the form or position of the nucleus. 



10. The lachrymal gland of the ox is not a mucous secreting 

 gland notwithstanding that the granules stain specifically in the 

 mucous stains. I do not agree with other observers, namely 

 Fleischer, that the secretion granules in the process of formation 

 regularly assume various peculiar forms such as rings and demi- 

 lunes. Rings and demilunes are sometimes seen in fixed prep- 

 arations but these peculiar forms are no doubt due to the action 

 of the fixation fluid. 



11. No light has been gained as a result of my studies on the 

 origin of secretion granules. The absence or at least the pres- 

 ence of very small amounts of demonstrable secretion granule 

 antecedent substances — prozymogen, nuclear derivatives, etc. — 

 does not admit of the hypothesis that the nucleus is the sole 

 originator of secretion granules. On the other hand the abun- 

 dance of granules, their variation in size without regard to position 

 in the cell (the largest and smallest granules are seen side by 

 side in any i)ortion of the cell), their apparent origin from the 

 cytoplasm — all strongly suggest that the cytoplasm plays a 



