456 WM. E. KELLICOTT 



some embryo. Certain organs, such as those of the circulatory 

 system — the heart, vessels and blood-cells — and the eyes, were 

 especially subject to abnormality, others such as the ears and 

 covering ectoderm were rarely affected; yet no structure was 

 found which was not affected in some degree in some embryo. 



By way of general support for this statement I may mention 

 just a few of the observed abnormalities, without mentioning 

 the details of the treatment in individual instances. 



In those cases where no definite embryo might be said to 

 have formed, such conditions as the following were noted : form- 

 less, non-cellular but living' protoplasmic masses; protoplasmic 

 masses with varying degrees of cellular structure; irregular pro- 

 toplasmic masses (probabty cellular) showing suggestions of 

 organs, such as brain fragments, lenses, portions of optic cups, 

 groups of somites, masses of erythrocytes, rhythmically contrac- 

 tile cells arranged either as, flat sheets or as tubular 'hearts,' 

 scattered pigment cells of the usual types, endothelial cells over 

 the surface of the yolk, fragments of notochordal tissue. 



Among those cases where a more or less complete embryo was 

 formed (connected with the preceding condition by various gra- 

 dations) a few of the abnormalities noted were the following: 

 two separate and complete embryos on a single yolk; absence of 

 head; absence of tail; large malformed head; short stumpy tail; 

 sinuous body and tail; short deep body and tail; malformed 

 pectoral fins; localized ectodermal proliferations; some regions of 

 the brain not closed dorsall}^; absence or hypertrophy of various 

 regions of the brain; various degrees of anterior approximation 

 and fusion of the eyes; ventral fusion of the eyes; absence of one 

 eye, the other remaining normal in size and position; eyes of 

 unequal size; optic cups not closed; various degrees of albinism 

 never quite complete; absence of certain types of pigment cells; 

 atypical concentrations of pigment cells; greatly dilated peri- 

 cardial cavity; heart abnormally placed, posterior or lateral to 

 its normal location; two hearts dissimilar in size and form, 

 asymmetrically located and with different rates of contraction; 

 absence of heart; heart short and 'telescoped;' heart elongated 

 and thread-like; heart long and dilated; heart flat and plate- 



