238 NAOKI SUGITA 
10. The underfed brains (Series II) contain on the average 
slightly (0.48 per cent) more water, if compared with the normal 
brain of the same age, and somewhat (1.4 per cent) less water, if 
compared with the normal brain of the same weight. This means 
probably that, in terms of the percentage of water, the underfed 
brain is slightly underdeveloped for its age and somewhat over- 
developed for its weight. If the absolute weight of the solid 
mass be calculated and compared with the standard for the same 
brain weight and sex, the solids are found to be somewhat more 
in the underfed and if the same compared with the standard for 
the same age and sex the solids are always less in the underfed. 
The relative value of the alcohol-extractives, obtained by com- 
paring the initial brain weight with its weight after dehydration 
and extraction in 80 per cent alcohol (for twenty-four hours) 
and 90 per cent alcohol (for twenty-four hours) according to a 
uniform procedure, shows that in the underfed brains the amount 
of the aleohol-extractives is somewhat smaller than in the normal 
of the same age. 
The above observations indicate that in the underfed the mye- 
lination process in the brain is somewhat retarded for the age. 
This assumption was supported in a general way by the direct 
examination on the sections obtained from the underfed brains. 
11. Briefly, we conclude that by starvation in the early days 
the brain suffers much in its development in toto, but the cell 
division is going on quite normally according to its age. The 
growth of the cells in size is retarded and the formation of mye- 
linated fibers somewhat diminished by inanition. So the smaller 
weight and size of the underfed brain is due to an arrest in the 
growth and development of the constituent neurons and not to a 
decrease in their number. 
