Literary Notices. cxv 



spread somewhat laterally in locomotion ; all four legs appeared some- 

 what ataxic, but hind legs more so ; incoordination of the limbs, espe- 

 cially of the hind legs, which were raised very high and placed so far 

 forward that they overstepped the forelegs in walking; peculiar move- 

 ments most marked when going slowly ; could jump off a stool, also raised 

 himself on his hind legs, but manifested, a disinclination toward doing 

 so ; volitional movements of the head and neck spasmodic and jerky ; he 

 trembled a great deal all the time, but especially after moving about ; his 

 sitting posture normal ; shook a good deal when turning around to look 

 out of the window ; eyes also normal ; tail rigid ; hind legs seemed a 

 trifle thin ; miowed and purred." 



"The results of the autopsy were negative save in the case of the 

 cerebellum, which was slightly smaller and more resistant to the knife 

 than the normal, and seemed shrunken, the cortex appearing rather thin; 

 fore-brain in normal condition; appeared well nourished ; viscera in good 

 condition; bladder full and distended ; spinal cord normal ; some fat in 

 canal ; nothing to be seen in sciatic nerves. The cerebellum and spinal 

 cord, as well as one lumbar and one dorsal spinal ganglion, were pre- 

 served for further examination and study." 



" Histology of the Molecular Layer. The small thread-like 

 fibres (radial fibres) in this layer, most of which run at right angles to 

 the surface, show much more clearly in the ataxic than in the normal, 

 giving to this layer (in the ataxic) a marked striate appearance. Indeed, 

 in the normal specimen, the course of the connective-tissue fibres cannot 

 be traced, while in the diseased portions of the ataxic specimen, one can 

 follow them as far as the Purkinje cell layer, to which their course is di- 

 rect. They run parallel to each other and without dividing. At their 

 peripheral ending, just at the pia, a few of these fibres branch, but the 

 majority end with pyramidal bases, the broad ends of which abut against 

 the inner surface of the pia. The Purkinje cell processes, which are 

 much thicker than the other fibres, branch and spread, and cannot be 

 traced to the periphery, but lose themselves before reaching the pia. 

 These processes always divide at a short distance from the Purkinje cells, 

 and this division occurs at a greater distance from the cell at the summit 

 of the folii than in the region at the base of the valleys. Throughout 

 the entire molecular layer are distributed small cells which show their 

 nuclei very clearly. This distribution is without any order, except that 

 the cells are more abundant in the regions contiguous to the Purkinje cell 



