126 Journal of Comparative Neurology. 



through the ganglia of the chani to the peripheral ganglia, or, 

 at most, give off only collateral branches in the chain-ganglia, 

 the fiber itself going to the periphery, and ending in some gan- 

 glion situated at a variable distance from the chain. 



Such medullated fibers constitute the white rami of the 

 peripheral ganglia. The central or pre-ganglionic fibers forming 

 such white rami differ only in length, not in structure, from 

 the central or pre-ganglionic fibers ending the ganglia of the 

 chain. 



There is reason to believe that a central fiber may end in 

 peri-cellular baskets in more than one ganglion, as Langley (87) 

 has shown and represents in several diagrammatic figures, and as 

 may be seen from Fig. (10) combined and slightly altered from 

 Langley's figures. 



In methylen-blue preparations of the sympathetic of the 

 frog, in which only a few fibers ending in baskets were stained, 

 I have several times observed that a medullated fiber — central 

 fiber — giving off one or two side branches, terminating in a spiral 

 and end basket, could be traced beyond the ganglion in which 

 these side branches were given off, into a neighboring ganglion. 

 These observations corroborate to some extent Langley's con- 

 clusions arrived at in experiments with nicotin. I have thus 

 far not succeeded in finding spiral fibers and end-baskets on the 

 same medullated fiber in two ganglia, but would think that in 

 suitable preparations such a fiber might be found. 



We are prepared, it seems to me, to formulate the follow- 

 ing conclusions. The sympathetic neurons, the cell bodies and 

 dendrites of which are grouped to form the sympathetic ganglia, 

 form the terminal link of a nerve or neuron chain, of which the 

 the second link is formed by a neuron, the cell body of which 

 is situated in the cerebro-spinal axis and the neuraxis of which 

 leaves the spinal cord or medulla through the anterior or motor 

 root as small medullated fibers, which fibers end in intra-capsular, 

 peri-cellular baskets, enclosing the cell bodies of the terminal — 

 sympathetic — neuron. An impulse issuing from the cord or 

 medulla along the central or pre-ganglionic fibers is transferred 

 to the cell body of a sympathetic neuron and thence along its 



