SPECIES IDENTITY OF NUCLEUS-PLASMA NORM 451 



of view of the cell, how much depression it takes to produce even 

 a symptom, to say nothing of actual unconsciousness. On the 

 possibility of affinities of localization for such ordinary depress- 

 ants, while not to be neglected, I look with some skepticism, for 

 one reason because in all the depressants studied the cerebellum 

 does become involved with repeated administration. At any 

 rate, the belief is based on abundant facts that ether may be 

 disregarded in the present connection as an active, anatomically 

 demonstrated depressant which might affect the resting cell, 

 and the uniformity of the results confirms its correctness. As a 

 matter of fact, the ether factor is not involved in many of the 

 present experiments. Outside of the operative cases, the animals 

 were killed in various ways — ^by chloroform, by illuminating gas, 

 and by stabbing after an initial nitrous oxide anesthesia. 



The essential characteristics of each animal follow in the order 

 of the table: 



Experiment Normal 13. A mongrel male pup, the best grown of 

 his litter. 



Experiment Normal 12. A nursing mongrel male pup, well nourished 

 and just able to walk well, whose cells showed a high degree of activity. 



Experiment Development 19. A well nourished and developed 

 female pup of pointer and bull strains, the mother being of pure breed. 



Experiment Muscular Exertion 30a. A female pup of shepherd 

 strain which died during etherization at the start of a lactic acid in- 

 jection and was used as a control. An extremely emaciated animal 

 which showed a marked degree of functional activity (See count in 

 table 1, 1914). 



Experiment Anesthetic 1. A lean mongrel, sex not noted. Cardiac 

 and respiratory failure occurred after a minimum of ether and efforts 

 at resuscitation were totally meffectual. In comiection with this 

 example of occasionally extreme susceptibility, it may be noted that 

 the animal showed the nearest approach to cellular exhaustion that 

 has ever been observed in an experimentally undisturbed animal, 

 more pronounced even than the usual profound shock condition. 



Experiment Normal 10. A fat female shepherd mongrel. 



Experiment Muscular Exertion 5. A well nourished male hound 

 pup of fairly pure strain. The control animal of the first muscular- 

 exertion series (1909). 



Experimental Muscular Exertion 3. A male from the same litter 

 as Experiment Muscular-Exertion 5. An extremely strong and active 

 animal which was exercised in the treadmill for one hour, one-fourth 

 of which time was distriluited as periods of rest. 



