452 DAVID H. DOLLEY 



r^xi)(>riiiient Muscular-l']xertion 32. A yomijj; adult femulc liouiul. 

 Tlie animal was exercised in the trca,dmill for two hours, of which time 

 somewhat less than half was devoted to rest, and then became the 

 donor in a repetition of Mosso's experiment of the transfusion of the 

 blood of fatigue (1914), in which it was well exsanguinated. The 

 total time of anesthesia before and after operation was one hour and 

 ten minutes. The. dog was in good training and stood the strain re- 

 markably. 



Experiment Shock 36. A well nourished mongrel female, whicli 

 was probably half-grown. Killed by accident by a stab into the medulla 

 during an operation which will be described under Experiment Cere- 

 bellar Section 4. The operation had lasted probal^ly some thirty 

 minutes. 



Experiment Shock 37. A well nourished and probably nearly grown 

 male pup, whose mother was a well-bred pointer. Died suddenly of 

 cardiac embolism in an experiment of introducing seeds into the arterial 

 circulation after an anesthesia and operation of forty minutes. 



Experiment Cerebellar Section 4. A very old mongrel male dog, 

 well nourished. The animal was killed twenty-seven days after a 

 craniotomy and a stab by a thin two-edged spear-like laiife into the 

 worm of the cerebellum parallel to its surface and at a depth of some 

 five millimeters. The purpose of this was to sever the axones of Pur- 

 kinje cells within a localized area and has been a phase of the corre- 

 lation and identification of the effects of axone resection with functional 

 depression within their physiological limits. At the time of death, 

 the animal was outwardly recovered, and, cytologically, outside of 

 depression and degeneration within the limited area of section, the 

 remaining parts of the cerebellum showed only thq normal changes 

 of activity with a smaller number than usual of cells at rest. That 

 is, whatever effect the various factors of operation and anesthetic may 

 have had were limited to functional excitation. The sections from which 

 the present measurements were made were taken from a lateral lobe. 

 There were many cells of senile type which offer no conflict with the 

 above analysis. 



Experiment Shock 38. A young adult male mongrel. Died from 

 a badly handled anesthesia in the course of an operation of ccrel^ellar 

 section. The operation had lasted probably thirty minutes. 



Experimental Normal 19. A fairly pure bred pointer, which had 

 given birth three weeks prior to death. A lean muscular animal of 

 large build. 



Experimental Muscular-Exertion 31 (1914). A female collie, show- 

 ing many cells of senile type. Experimentally, the animal had received 

 intravenously under ether 350 cc. of a 5 per cent solution of lactic 

 acid in warm saline, a total of 17.5 cc. of the full strength acid. She 

 showed the usual symptoms of apathy and sleepiness and vomited. 

 At the time of killing, which was after five and one-half hours, the 

 symptoms were still preceptible though less marked. This animal 

 was chosen purposely to see if the measurements confirmed the ob- 



