480 DAVID H. DOLLEY 



the hyperchromatism, the shrinkage with subsiding hyperchro- 

 matism, the secondary enlargement coincident with hypo- 

 chromatism (functional hypertrophy), etc. The nucleus-plasma 

 changes which result are as fixed and constant as is the relation 

 in the resting cell — they are founded on that relation. Func- 

 tion is not an intangible thing — definite anatomical states sub- 

 tend it. 



The facts already brought out of constant constitution and 

 nucleus-plasma relation prove the resting cell as a type apart. 

 In diverse functional states it has remained a constant. Further, 

 the essential nature of the sequence of changes denominated 

 active denotes that something far and away different in degree 

 is taking place in the functioning cell as distinguished from the 

 resting cell. The changes can only mean a vastly increased 

 intake, upbuilding, coincident with a vastly increased outgo, 

 which latter soon gains the advantage and leads to imbalance 

 of the cell and nucleus. Energy is being rapidly elaborated, 

 rapidly dissipated. Contrast that with the equilibrium of the 

 resting cell which is always the same. It makes no difference 

 how severe or prolonged is the stimulation, how widespread the 

 reaction. Until it is actively engaged, the fixed type of resting 

 cell holds. Even in the most profound activity, it is rare not to 

 find some of this type. And if for illustration only one is left, 

 not only would that one have all the characteristics of stain and 

 content, but the indication appears sufficient that by serial 

 section and reconstruction the ratio of its plasma to its nucleus 

 would be a measured constant. With these facts, one is justified 

 in limiting function to certain numerous types, rest to a single 

 solitary type. With these facts, would it satisfy reason that 

 function passes through an intangible thing, originating from and 

 affecting all types of cells alike?. Function cannot affect the 

 resting cell as such without making it a functioning cell. The 

 quantitative reaction of function is eliminated as a biologic 

 factor affecting the nucleus-plasma relation of the resting cell 

 as such. 



The second group included in pure function, namely, the 

 quantitative reaction of a single phase of activity which takes 



