488 DAVID H. DOLLEY 



all the Purkinje cells were affected and the condition ranged 

 from a slight to a marked physiological degree, occasionally to 

 frank degeneration, but more cells were affected than remained 

 normal. The results of measurements are recorded in the second 

 division of table 5. First twenty-five resting cells were measured 

 as usual, taking them as they came whether without depression 

 or with depression of slight, moderate, or marked degree. The 

 coefficient figure, 10.09, was very noteworthy, but still open to 

 doubt. Another set was measured from different sections. The 

 second figure differed only by one-half a point, and was still 

 lower than any variation in the regular series of most likely 

 technical origin. The slightly larger size in the second series is 

 readily explained as due to the purposeful inclusion of some cells 

 just passing from rest into activity and hence slightly larger. As 

 a further test it was decided to measure a series belonging to the 

 initial stage of activity. They are much more favorable because, 

 being toward the maximum of initial enlargement with a fairly 

 uniform hyperchromatism, confusion in diagnosis is impossible 

 and the size is more uniform. Of the twenty-five of this group 

 measured, nine were recorded as slight, nine as moderate, and 

 seven as severe examples of depression. The resultant coefficient 

 was 9.09. - 



Finally, a fourth series of resting cells was measured. These 

 were most carefully selected, not because they showed a relatively 

 large nucleus but because they exhibited definite standards of 

 depression, and further they were chosen to correspond as 

 closely as might be to the third series in degree of depression, 

 nine being slightly, nine moderately and seven severely depressed. 

 The resulting coefficient figure was 9.76. Granting the accuracy 

 of such selective measurements, the result in the third and fourth 

 series are beyond all reasonable question a result of the disturbed 

 functional state. Depression results in a measurable quantita- 

 tive upset in favor of the nucleus. The fairly close correspond- 

 ence of the coefficient figures in the third and fourth series is 

 highly important. The normal resting cell and the first stage of 

 normal activity have a common ratio. So they would appear to 

 have in depression. But in depression this ratio is expressed 



