•49S DAVID H. DOLLEY 



2. The resting nerve cell as a type distinct from the numerous 

 phases of the functioning cell is moi'phologically fully defined. 

 In addition to its general characteristics, it has the nucleus- 

 plasma relation common to its type for the species. 



3. The sole biologic factors which change the constancy of 

 the nucleus-plasma norm of the resting cell as such are two^ 

 functional depression and functional senility. 



4. Under this law, the principle of the quantitative nature of 

 the nerve cell's reaction is established. Correlative with the 

 evidence for an exact quantitative interchange between plasma 

 and nucleus for every phase of functional activity, the reaction 

 of function starts from a fixed quantitative ratio of nucleus to 

 plasma and returns in recovery to that same ratio under normal 

 conditions until old age incapacitates. 



5. A new basis of comparison of the variability between 

 individuals results from a fixed identity of mass relations for a 

 species. On the side of the cellular reaction, if the special bio- 

 logic factors of deviation, namely, functional senility and func- 

 tional depression, be excluded, the factors of variability in func- 

 tioning power and capacity between one individual and another 

 are reduced to two — first, the differences in absolute size of cells, 

 and second, the differences in the quality of the protoplasm. 



BIBLIOGRAPHY 



Adami, J. G. 1910 Principles of pathology, vol. 1, p. 508. 



CoNKLiN, E. G. 1912 a Cell size and nuclear size. Jour. Exper. Zool., vol. 12. 



1912 b Body size and cell size. Jour. Morph., vol. 23. 

 Chile, G. W., and Dolley, D. H. 1908 On the effect of the complete anemia 



of the central nervous system in dogs resuscitated after relative death. 



Jour. Exper. Med., vol. 10. 

 DoLLEY, D. H. 1909 The neurocytological reaction in muscular exertion. 



Amer. Jour. Phys., vol. 25. 



1910 The pathological cytology of surgical shock. II. Jour. Med. 

 Research, vol. 22. 



1911 a Studies on the recuperation of nerve cells after functional 

 activity from youth to senility. .lour. Med. Research, vol. 24. 



1911 b The identity in dog and man of the sequence of changes pro- 

 duced by functional activity in the Purkinje cell of the cei'cbellum. 

 Jour. Med. Research, vol. 25. 



