274 KIYOYASU MARUI 



with a different .size and shape (fig. 10). This was also the case 

 with the methyl-blue granules and the fuchsinophile granules. 

 All these granules were embedded in the evenly and lightly 

 stained ground substance, which is to be interpreted as the sec- 

 tion of the cell body or the process of the glia cell. As far as 

 my observation reached, these granules did not lie free in the 

 space around the blood-vessel or in the tissue. 



The cells of the adventitia of blood-vessels in the normal brain 

 show very little protoplasm around their nuclei; but in fatigue 

 cases, when a number of amoeboid glia cells are present around the 

 vessels, they show a larger mass of protoplasm. In the thionin- 

 eosin preparation I observed occasionally the metachromatic 

 basophileg ranules in them. Scharlach R (fig. 13) revealed many 

 fat drops in the latter. It must be added here that in the 

 neuroglia cells around the vessel and in the sjniapse fat drops were 

 demonstrated within the protoplasm. According to my obser- 

 vation, there was, however, very little fat lying in the tissue or 

 in the space around the vessel. 



THE 'FUELLKOERPERCHEN' OF ALZHEI^IER 



P 



After the description of the changes of the glious reticulum and 

 the glia cells of the synapse, one more manifestation, which goes 

 hand in hand with the appearance of the amoeboid glia cells is to 

 be mentioned. I have already described that in sections in which 

 a number of typical amoeboid glia cells were observable, many a 

 protoplasm mass of different size and shape appears in the peri- 

 vascular space and in the other parts of the synapse. These pro- 

 toplasm masses were found to be sometimes homogeneous and 

 sometimes granular and they occurred usually near the amoeboid 

 glia cells. Some of these masses must be regarded as the section 

 of the cell body or the process of an amoeboid glia cell (fig. 10); 

 but some of them show evidently that they were cast off from the 

 body of the amoeboid glia cells (fig. 15). It was also related 

 above that the processes of the glia cells, which are not in possession 

 of the proper attributes of an amoeboid glia cell are broken up in 

 their substance and are reduced to fragments. I assume that I 



