XC11 



Journal of Comparative Neurology. 



15th that the canals are approximately distinct. Experiments showed 

 that up to the 14th day there was no suggestion of rotary or forced 

 motions after the passive rotation, while on the 15th it was obvious 

 and increased for some time thereafter. The coincidence between the 

 time when the canals become anatomically differentiated and that at 

 which the effects of dizziness first appear is construed as evidence in 

 favor of the theory that the labyrinth has a static function. 



Neuro-Muscular Changes in General Paralysis. 1 



The history of twelve cases of general paralysis of the insane 

 with autopsies and full histological examination. The following points 

 are taken from the author's synopsis : 

 Changes in the Vagi. In all cases 

 extensively and strikingly diseased, 

 more so almost than any of the periph- 

 eral nerves, and decidedly more so 

 than any cranial nerve. Too much 

 importance cannot be attached to the 

 remarkable singling out of the vagi 

 for such extreme degeneration in this 

 disease. A similar affection obtains 

 in alcoholic polyneuritis, a disease dis- 

 tinctly produced by a toxic infection, 

 also in other diseases ( diphtheria, etc.), 

 and in all it is unquestionably account- 

 able for serious clinical changes. In 

 general paralysis it explains the car- 

 diac troubles so often met with. An- 

 atomically, most pronounced degener- 

 ative changes were demonstrated in 

 the muscular elements of the heart in 

 cases in which the vagi were diseased, 

 diseased, but less so than the vagus trunks. 



Changes in the mixed spinal nerves and their peripheral terminations. 

 The alteration appears to be a combination of a parenchymatous de- 

 generation and an interstitial or adventitial inflammation. The exist- 



Fig 1. Transverse section of Vagus. 

 Weigert's method, a, healthy nerve 

 fibres; b, unstained fibro-eellular tis- 

 sue (remains of diseased fibres;) c, ex- 

 tremely diseased large bundle contain- 

 ing few healthy fibres: d, thickened 

 perineureum. 



Phrenic nerves were always 



Campbell, Alfred W. A Contribution to the Morbid Anatomy and 

 Pathology of the Neuro-Muscular Changes in General Paralysis of the Insane. 

 /oar. Men. Set'., XL, 169, April, 1894. 



