CLINICAL IMPROVEMENT 
TABLE 1 
HISTOLOGICAL CONDITION 
Spinal cord 
ment 
ment 
Roots and nerves 
Mass of débris including broken down myelin and blood, which is entered by granulation tissue from pia and dura. This 
granulation tissue more dense toward periphery. In the interior there are young fibro blasts with elongated nuclei. 
Also many new capillaries. Compound granular cells, small round cells and leucocytes also present. Areas of beginning 
Granulation tissue denser than above. Many myelin droplets 
left. Some fibroblasts and compound granular cells. Less débris than in above. Leucocytes and round cells in new 
connect. tissue. Little repair in grey matter. Some ant. horn cells swollen and pale. 
Dense scar with small cavities adjoining. These contain a little débris and a few myelin drops small in size. Some small 
nerve fibers, perhaps new, entering cavities. Many round cells. 
Zone of dense scar from dura. Nextazone of less well organized connect. tissue containing in its meshes compound granu- 
lar cells and myelin drops. Next a zone of a relatively few fibro blasts and myelin drops, débris in large amounts and 
old blood. Finally normal cord substance. Some ant. horn cells are bloated. 
One main large cavity, which is lined by thin layer of new connect. tissue. Ant. horn cells show bloating and chromatolysis. 
Many leucocytes and new vessels. 
Much dense sear. Two large cavities still containing the remains of myelin in small amounts. 
Large cavity, which tends to follow outline of grey matter. 
Ant. horn cells pale and bloated, having lost their polygonal shapes. 
Broken down tissue in grey matter. 
Cavities. 
Light connect. tissue and areas of partial necrosis in grey matter. Some dense scar with cavities. 
Dense scar. 
When first noticed One month after lesion Two wee after Biante Aes 
No improvement 
necrosis in neighboring grey matter. 
Distinct improvement Similar to above. 
noted on 5th day 
Distinct improvement | Improvement Marked formation of cavity divided into compartments. 
noted on 5th day 
Distinct improvement | Improvement Similar to above. 
noted on 6th day 
Distinct improvement | Improvement Similar to above. 
noted on 11th day 
Distinct improvement | Improvement Similar to above. 
noted on 9th day 
No improvement No change No change 
Distinct improvement | No change No change 
noted on 9th day 
Gradual improvement | Improvement No change 
Gradual improvement | Improvement Improvement Slight improve- | Dense scar with large patches of round cells. 
ment 
Gradual improvement | Improvement Improvement Slight improve- 
ment Distortion of grey matter. 
Ant. horn cells often bloated and show chromatolysis. 
Distinct improvement | Improvement Slight improve- | No change Much dense scar. 
: ment Distortion of grey matter. Vacuolation of ant. horn cells. 
Distinct improvement | Improvement Improvement No change Much dense scar containing cavities. 
noted on 13th day 
Gradual improvement | Improvement Improvement No change Dense scar and cavities. 
Vacuolation of ant. horn cells. 
Gradual improvement | Improvement Improvement No change Dense scar containing cavities. 
Gradual improvement | Improvement Slight improve- | Slight improve- | Dense scar, débris and light connective tissue. 
ment ment Distortion of grey matter. 
Distinct improvement | Improvement Slight improve- | No change 
noted on 6th day ment 
Distinct improvement | Improvement Slight improve- | No change 2 large cavities, one of which follows outlines of grey matter. 
noted on 6th day ment 
Gradual improvement | Improvement Improvement Slight improve- | 1 large cavity. Thick scar in dura. 
ment 
Gradual improvement | Improvement Slight improve- Slight improve- 
Dense and light scar, one cavity, débris and remains of myelin. 
Areas of necrosis in grey matter. 
Ant. horn cells often swollen, bloated and pale. 
Marked degeneration 
in some of the fibers 
Similar to above 
Similar to above 
Similar to above 
Complete or almost 
complete degen. of 
some of the fibers 
Similar to above 
Similar to above 
Some remains of bro- 
ken down myelin in 
fibers 
Some beginning regen- 
eration 
Some fibers show signs 
of degeneration. 
Others suggest new 
regeneration 
Similar to above 
Increase in connect. tis- 
sue in nerve trunks 
Similar to above 
Similar to above 
Signs of new regenera- 
tion in roots 
Good regeneration of 
many fibers 
Similar to above 
Similar to above 
Similar to above 
Similar to above 
THE JOURNAL OF COMPARATIVE NEUROLOGY, VOL. 22, No, 2 
