author's abstract op this paper issued 

 by the bibliographic service october 6. 



THE CELL-CHANGES IN THE HYPOPHYSIS OF THE 

 ALBINO RAT, AFTER CASTRATION 



WILLIAM H. F. ADDISON 



From the Anatomical Laboratory, University of Pennsylvania and 

 The Wistar Institute of Anatomy and Biology 



FIVE FIGURES 



CONTENTS 



Introduction 441 



Material and methods 442 



Normal hypophysis 443 



Experimented hypophysis 448 



One month after castration (69 days old) 449 



Two months after castration (98 days old) 451 



Three months after castration (135 days old) 452 



Five months after castration (179 days old) 454 



Seven months after castration (246 days old) 454 



Discussion of observations 455 



Relation between interstitial cells and hypophysis 459 



Summary 459 



Literature cited 460 



INTRODUCTION 



The operation of castration in the albino rat is followed by 

 definite progressive alterations in the structure of the ventral 

 glandular portion (pars anterior) of the hypophysis. Indeed, 

 aside from the atrophy of the several related organs of the re- 

 productive system and the diminution of the secondary sexual 

 characters, the cytomorphic changes in this portion of the 

 hypophysis present one of the most striking phenomena result- 

 ing from castration. This suggests that perhaps the growth 

 changes, recorded in various organs and tissues after castration, 

 are influenced by this alteration in the structure and physio- 

 logical activity of the hypophysis. The study of the changes in 

 the hypophysis after castration also affords evidence in regard to 



441 



