448 WILLIAM H. F. ADDISON 



as a mass, sometimes rounded, sometimes elongated or irregular, 

 separated by a lighter zone from the surrounding cytoplasm. 

 It is always adjacent to the nucleus, and persists in the experi- 

 mented hypophyses. After methods of preparation used for 

 demonstrating the Golgi network, it shows, in favorable speci- 

 mens, as a close-meshed reticulum. For this reason, I have 

 considered it (Proc. Am. Assoc. Anat., Anat. Rec, January, 

 1917) to be the structure described as the network apparatus of 

 Golgi. Gemelli ('00) has pictured a larger looser network in 

 the cells of the hypophysis of animals other than rat, using the 

 early method of Golgi for demonstrating this structure. Soyer 

 ('12), however, has found a structure near the nucleus in the 

 glandular cells of the human hypophysis, which he considers 

 merely to be a large centrosphere, and in it he has stained the 

 pair of centrioles. Deineka ('12) has found that in many 

 cases where the position of the centrosphere is known, the posi- 

 tion of the net-apparatus agrees with it (cells of Descemet's mem- 

 brane, leucocytes, medullary cells of adrenal). Basile ('15) in 

 renal epithelium finds support for the hypothesis of Barinetti, 

 that the reticular apparatus and the centrosomes present a 

 union, anatomical and functional. 



In \dew of these several highly interesting observations, it 

 has seemed best to term the body which one sees in the cells of 

 the hypophysis, macula, until further information is forth- 

 coming. In the basophiles the macula is much larger than in 

 the acidophiles, and by measurement one finds that it increases 

 with the size of the entire cell (table 3). 



EXPERIMENTED HYPOPHYSIS 



After castration there quickly ensues a reaction, which is 

 discernible in a week, readily apparent in two weeks, and which 

 is progressive throughout the life of the animal. Grossly, 

 there is a color change which is due to the increased amount of 

 blood in the vascular channels, and this hyperaemia no doubt 

 contributes to the increased weight of the organ. Histologically, 

 the first changes are seen in the basophiles, and in the reserve 



