450 WILLIAM H. F. ADDISON 



which have been produced due to the experimental procedure. 

 The most evident effect is the increased size of the basophiles. 

 and this, with their greater stainabihty, makes them much more 

 conspicuous than in the normal sections. The basophiles, 

 however, are not all of the same size, there being many of smaller 

 diameter, and these are probably to be regarded as reserve cells, 

 which have recently differentiated into basophiles. The acido- 

 philes are numerous and very evident, and only slight changes 

 from the normal were noted. The reserve cells show as groups 

 of less conspicuous elements scattered throughout. Other 

 changes, not shown in figure 2, are the increased diameter of the 

 blood vessels and the constant presence of the colloid-like secre- 

 tion in the residual pouch of Rathke. 



Measurements of the basophiles showed them to average 

 17.9 fj. X 14.3 fj., in contrast with the normal cells of the same age 

 which measured 13.5 ju x 11.5ju, but many individual cells in the 

 experimented hypophysis exceeded this size considerably, and 

 so helped to accentuate the impression of the large size of this 

 type of cell. The nuclei of the cells showed a similar contrast 

 between experimented and normal, measuring in the former, 

 6.7 // x 5.8 M, and in the latter 5.8 /x x 4.8/^. By measurement it 

 was found that the acidophiles were retarded slightly in their 

 growth, averaging 11.5 ^i x 8.0 fx in the normal, and 10.0 ^u x 7.7 /x 

 in the experimented. At 45 days of age, the normal acidophiles 

 measure 9.6 /x x 7.5 ju, so that these experimented animals at 

 69 days of age, had acidophiles very slightly larger than the 

 normal animal of 45 days. 



Measurements of the reserve cells showed that their nuclei 

 increased .slightly (from 5.9 n x 4.6 ^ normally to 6.1 /xx5.1 /x in the 

 experimented). This probably has little significance, for while 

 it may be due to a real growth of reserve cell nculei, participated 

 in by all, it may be due to the inclusion in the cells measured of 

 one or two cells which are beginning to differentiate and to grow 

 into basophiles. 



