460 WILLIAM H. F. ADDISON 



3. The basophiles, after certain fixations, show a large cyto- 

 plasmic body (macula), which may be the reticular apparatus 

 of Golgi, or centrosphere, or both combined. The acidophiles 

 show a similar structure, much smaller in size. 



4. The experiments afford strong evidence for the view that 

 there are at least two actively functionating types of cells in this 

 part of the hypophysis and that both of these are derived in 

 histogenesis from a less differentiated form (reserve cells) . Some 

 of the latter persist during mature life, and serve as the source 

 of supply for the other two types. 



In conclusion, I wish to thank Professor Piersol for advice 

 and criticism, and Professor Donaldson, of The Wistar Institute, 

 for constant interest in the study. I also wish to acknowledge 

 the kind assistance of Mr. E. F. Faber, instructor in art in the 

 School of Medicine, in the preparation of the drawings. 



LITERATURE CITED 



Barnabo 1908 Sui rapporti tra la glandola interstiziale del testicolo e le 



glandole a secrezione interna. Policlinico, vol. 15, pp. 134—144. 

 Basile, G. 1915 Sulle modificazioni dell'apparato reticolare interne di Golgi 



nell 'epitelio renale di animali nefrectomizzati. Intern. Monatsch. 



ftir Anat. u. Phys., Bd. 31, pp. 1-5. 

 Bensley, R. R. 1911 Studies in the pancreas of the guinea-pig. Am. Jour. 



Anat., vol. 12, pp. 297-388. 

 BiEDL, A. 1912 Innere Sekretion, Berlin, vol. 2, p. 107 et seq. 

 CiMORiNi, A. 1908 Sur I'hypertrophie de I'hypophyse cerebrale chez les ani- 



maux thyreoidectomises. Arch. Ital. Biol., vol. 48, pp. 387-400. 

 CowDRY, E. V. 1916 The structure of chromophile cells of the nervous system. 



Publ. 224 of the Carnegie Institution of Washington. Contribution to 



Embryology, No. 11, pp. 27-43. 

 Deineka 1912 Der Netzapparat von Golgi in einigen Epithel- und Binde- 



gewebszellen wahrend der Ruhe, und wahrend der Teilung der selben. 



Anat. Anz., Bd. 41, pp. 289-309. 

 FiCHERA, 1905 Sulla ipertrofia della ghiandola pituitaria consecutiva alia 



castrazione. II Policlinico, vol. 12. 



1905 Sur I'hypertrophie de la glande pituitaire consecutive k la 



castration. Arch. Ital. Biol., vol. 43. 

 Gemelli, E. 1900 Contributo alia conoscenza sulla struttura della ghiandola 



pituitaria nei mammiferi. Boll. Soc. Med. Chir., Pa via, pp. 231-242. 

 Hatai, S. 1913 The effect of castration, spaying or semi-spaying on the 



weight of the central nervous system and of the hypophysis of the 



albino rat. .lour. Exp. Zool., vol. 15, pp. 297-314. 



