author's, ABSTRACT OP THIS PAPER ISSUED BT 

 THE BIBLIOGRAPHIC SERVICE, SEPTEMBER, 28 



THE RECOVERY FROM DEPRESSION IN THE PUR- 

 KINJE CELL AND THE DECLINE TO SENILITY 

 OF DEPRESSION: WITH THE INCIDENTAL HIS- 

 TOGENESIS OF ABNORMAL PIGMENTATION 



DAVID H. DOLLEY 

 From the Pathological Laboratory of the University of Missouri 



CONTENTS 



Data of experiments 465 



The recovery without or with temporary disorganization 467 



The recovery with permanent disorganization (senility of depression) 471 



The decrease of chromatic substance 472 



Cell death and cell atrophy 473 



Reorganization of the nuclear membrane and its failure 474 



The potentiality of recovery from depression as compared with that 



from organic exhaustion 475 



The histogenesis of abnormal pigmentation 477 



The duality of the senescent process in the nerve cell (senility of function 



and senility of depression) 483 



Conclusions 490 



This study completes the immediate and the remote cycle re- 

 sulting from the depression of function, of which the retrogressive 

 phase has been previously presented ('13). 



DATA OF EXPERIMENTS 



All depressant agents produce a common reaction. The choice 

 was therefore governed by convenience. The aim was to pro- 

 duce the maximum of depression which experience had taught 

 was compatible with safe recovery. The animals were known to 

 be young. 



Ether 



For these experiments, I am indebted to Mr. E. E. Butler ('16), 

 who kindly performed them for this study of recovery in connection 

 with his work on immediate depression. 



465 



THE JOURNAL OF COMPARATIVE NEUROLOGY, VOL. 28, NO. 3 

 DECEMBER, 1917 



