466 DAVID H. DOLLEY 



Experiment anesthesia 13. Dog, female, 4 kg., aged 2 years. Six 

 periods of administration, averaging over 4 hours and h pound of ether 

 each. Three administrations from 1 to 3 days apart, then a rest 

 of 10 days, followed by the remaining three. Duration of exeriment 

 24 days. Recovery period after last administration 6 days. 



Experiment anesthesia IJ^. Dog, male, 9.58 kg., aged about 3 j^ears. 

 Nine periods of administration, averaging 4| hours and one pound of 

 ether each. Five administrations 1 to 3 days apart, a rest of 18 days, 

 then the remaining four. Duration of experiment 45 days. Recovery 

 period after last 'administration 13 days. 



Experiment anesthesia 16. Dog, female, 8 kg., aged 3 years. Five 

 periods of administration in 41 days. Followed after one week by a 

 series of morphine injections carried over 67 days to the number of 30. 

 Dose was raised from 0.04 to 0.2 gram at the end. Duration of experi- 

 ment 170 days. Recovery period after ether 128 days, after morphine 

 52 days. 



MorpJiine 



Experiment morpJiine 4- Rabbit, 1.5 kg. Administered hypoder- 

 matically over a period of 71 days, somewhat irregularly but usually 

 every other day. Dosage raised from the initial 0.007 to 0.133 gram 

 per kg. at end. Duration of recovery after last dose 42 days. 



Experiment morphine 6. Rabbit, 1.7 kg. Administered hypoder- 

 matically every day for 47 days. Dosage raised from 0.020 to 0.035 

 gram per kilogram. The same dosage though lowered toward the end 

 killed a companion rabbit (Morphine 5) when the administration was 

 stopped. Duration of recovery 28 days. 



Heat 



Experiments heat 11 and 12 , Two rabbits carried simultaneously in 

 a hot air oven. There were eight exposures, on successive days, rang- 

 ing from 1 hour to 2 hours and 45 minutes, at a temperature around 

 45°C. The exhaustion each time was moderate, never destroying an 

 immediate interest in food. For profundity of reaction there is no agent 

 so effective as heat. Experiment 11 was allowed to live 21 days and 

 Experiment 12 six months. 



Axone section 



Much information is owed to the study of the cutting of 

 Purkinje cell axones made by W. D. Davis in this laboratory (un- 

 published thesis for the Master's Degree, '14). The degenerative 

 changes have been identified anatomically as depression phe- 

 nomena, and physiologically are to be correlated with the loss 

 of functional tonus and of active functional stimuli. The changes 



