THE RECOVERY FROM DEPRESSION 471 



disorganizatron. They are cited here for the hght they shed on 

 the regular course of complete recovery. 



The conti-ast between the recovery from exhaustive functional 

 activity and that from depression may accordingly be summarized 

 as follows:' 



RecovcTy from activity Recovery from depression 



Cytoplasm 



Size: A shrinkage; plus renewal of sub- A growth, renewal of substance only; 



stance; usually the first feature of the last feature of complete recovery. 



complete recover''y. 



Chromatic contpjnt: Relative to de- The first feature of complete recovery — 



pression slowly- Second feature or a nuclear phenomenon. 



associated wi th size. 



« Nucleus 



Size: A growth " of materials; slow^ to The excess materials are reduced by 

 recover. , renewed cytoplasmic resorption and 



further synthesis. 

 KaT-^yosome : The last feature of re- An early feature, probably along with 

 covery. cytoplasmic restoration of chromatic 



substance. 

 Chromatin independent of karyosome : Reduction of chromatin in excess. 

 Where it normally appears a rela- 

 tive deficiency until the end of the 

 process. 

 Nucleolar substance: Slow, a syn- Recovery proceeds on an unaffected 

 thetic growth. or increased absolute amount. 



Time relations 



Measured in weeks and months — the Measured in days as regards chromatic 

 nucleus in disadvantage. substance — the nucleus in advantage. 



THE RECOVERY WITH PERMANENT DISORGANIZATION (SENILITY 



OF DEPRESSION) 



A permanent cellular disorganization rests clearly on the an- 

 lage of acute depression. The antecedent of the permanent state 

 in this experimental work is the degenerative or better necrobiotic 

 climax of severe depression. The term degenerative is only used 

 to apply to the continuation of the same physiological process, 

 though to some degree finally a modified process, not in the 

 sense of a fixed pathological condition. From the principles in- 



