THE RECOVERY FROM DEPRESSION 475 



Popoff, '07, for Paramaecium ; Howard and Schultz, '11, for 

 tumor cells; Dolley, '13). 



If one could apply to the nerve cell the work of Albrecht ('02) 

 which substitutes the conclusion of a 'fluid partition wall, neither 

 mixing with the cytoplasm nor with the nucleus, for the usual 

 conception of an individualized, contingently porous, not fluid, 

 or even doubled nuclear membrane' (Gurwitsch, '04, p. 20), the 

 process of its being laid down anew would be hypotheticallj^ 

 more easily conceived. Further, it is stated by Gurwitsch, who 

 cites Albrecht's work at length, that this different partition 

 layer, comparable to the ectoplasm of the amoeba, must be able 

 both to differentiate itself from the nuclear substance and to 

 mix with it again. 



Does this loss of nuclear integrity become permanent in 

 chronic states? Here belong the formless knobs of atrophic 

 anucleated cells already mentioned, with isolated chromatic 

 granules. Certainly the anucleated state is found after months 

 of recovery, but such a state may be only a phase of a continuous 

 retrogression to death, not relatively more permanent. On a 

 final permanent inability to relocalize a nucleus, though nuclear 

 materials are present, I am not able yet to speak positively, as 

 it is a unique phenomenon. Objectively and theoretically, lam 

 inclined to believe it possible and compatible with function for 

 some little time. Search through the ordinary sources for in- 

 formation on this point has been fruitless. This is rather to be 

 expected, for it falls without the domain of normal cytology, and 

 further for the nerve cell in which the Nissl substance is not yet 

 conceded generally to be of nuclear origin, the presence of that 

 substance without a formed nucleus would not suggest the 

 possibilities. 



The potentiality of recovery from depression as compared with that 

 from organic exhaustion 



Depression, both acute and chronic, would appear to have a 

 greater potentiality of recovery than organic exhaustion, even 

 to the senile state. The more rapid restoration of the chromatic 

 substance has already been discussed. In this, as in other 



