310 DAVID H. DOLLEY 
from stages 10 to 13, in which the state of the karyosome is the 
criterion. The karyosome is thus most rarely invisible. The 
cells which could not be exactly identified because not suffi- 
ciently in section were listed as hyperchromatic and hypochro- 
matic, as has always been the practice. The differences in the 
counts submitted are as striking as in the diagnosed cells. Un- 
less the differences are as marked as in the present case I do not 
consider a count of less than 200 actually diagnosed cells in imi- 
tation of Kocher as adequate, but the survey of 77 paired sec- 
tions in this instance showed obviously that the general dis- 
tribution was that of the count. 
Table 1 may be summarized as follows: The transition to up- 
set of the nucleus-plasma relation begins toward the end of the 
Hodge stage 5, actually with stage 5”. This is a convenient 
point of demarcation for comparison. In the control animal, 
173 resting and early type cells, including stage 1-5’, are found, 
while in the other only 25 early type cells, with no resting cells 
at all, show the effect of exercise in driving cells beyond the 
early stages. On the other hand, there are only 19 cells in vari- 
ous stages of upset of the nucleus-plasma relation in the con- 
trol as contrasted with 126 in the exercised animal. Taking the 
undiagnosed cells, the hyperchromatic ones belong between 
stages 1 and 5, the hypochromatic ones to the period of upset. 
The ratio in the control is 105 to 7, in the exercised animal 27 
to 122. The quantitative difference between action and in- 
action is everywhere displayed. 
It is also worth while to point out that there are no exhausted 
cells, namely, dechromatized in nucleus and plasma, in either 
case. The exercised puppy was not exhausted in the organic 
sense, but had much reserve. Its immediate distress, so far as 
it was nervous, came from the other side of fatigue, the waste 
product reaction. With rest and elimination, it could have gone 
on, as fits experience. Evén the finding of a quota of exhausted 
cells does not indicate exhaustion of capacity—so long as there 
are other cells. 
