A CASE OF CYCLOPIA 243 



5. That the initial stimulus resulting in the differentiation of 

 specialized efferent cortical neurones is probably dependent upon 

 the arrival of these afferent fibers in the cortex. 



6. That the condition of development in the cerebrum of this 

 case offers further proof that the differentiation of the cortex 

 into histologically distinct areas precedes the development of the 

 convolutional pattern. 



(1 



(2 



(3 

 (4 

 (5 



(6 



(7 



(8 



(9 



(10 



LITERATURE CITEDi 



Blackburn, I. W. 1907 Anomalies of the encephalic arteries among the 

 insane. Jour. Comp. Neur., vol. 17., no. 6. 



Bolton, J. S. 1910 A contribution to the localization of cerebral func- 

 tion based on clinico-pathological study of mental disease. Brain, 

 vol. 33. 



Bolton, J. S. and Moyes, J. M. 1912 The cytoarchitecture of the cere- 

 bral cortex of a human foetus of eighteen weeks. Brain, vol. 35. 



Bonne, Ch. 1908 L'ccorce cerebrale. Revue Generale d'Histologie, 

 Renaut et Regaud, no. 2. 



Cajal, S. Ram6n 1909 Histologie du systeme nerveux de I'homme et des 

 vertcbrcs. Trad, par Azoulay, tome 1. 

 1911 Idem, tome 2. 



Campbell, Alfred W. 1905 Histological studies on the localization of 

 cerebral function. Cambridge. 



Dareste, C. 1S91 Recherches sur la production artificielle des monstres. 

 II Ed. Paris. 



Gravelotte, E. 1905 Contribution k I'eiude des anomalies dedcveloppe- 

 ment de I'extremite cephalique — un cas de cyclopie. These. 



Harrison, R. G. 1906 Further experiments on the development of periph- 

 eral nerves. Am. Jour. Anat., vol. 5. 



1 No attempt has been made here to prepare a complete bibliography of the 

 literature dealing with cyclopia, for the great majority of the cases reported have 

 no bearing upon the subject of this paper. A complete critical review of the lit- 

 erature up to 1872 has been made by Kundrat (12). For a short review of the 

 subject of cyclopia up to 1897 and a statement of the various theories that have 

 been held regarding the nature and cause of this malformation, reference may 

 be made to Naegeli's paper (17). A somewhat more extensive historical survey 

 of the subject, with a bibliography may be found in the thesis by Gravelotte (9). 

 Most of the important contributions of recent date on this subject have been 

 made by the application of experimental methods in the production of this mal- 

 formation in lower forms. Some of the more important papers in this connection 

 are cited, as well as some of the literature bearing upon the general subject of 

 teratology. Papers dealing with the histological arrangement of the elements 

 in the normal cortex, which have been consulted in connection with the study of 

 the cortex in this case, are also referred to in this list. 



