48 LEO LOEB 
OVARIES OF A GUINEA PIG APPROXIMATELY THREE TO FOUR 
DAYS AFTER ABORTION 
In one case the ovaries of a guinea pig were examined which on 
examination had previously been found to be in a well developed 
stage of pregnancy, but which had aborted about three to four 
days previously. The four corpora lutea showed signs of degener- 
ation. The lutein cells were vacuolar in the periphery, in the cen- 
ter the cells stained pale red with eosin, the vesicular nuclei 
showed a diminution in the amount of chromatin. The cell out- 
lines were very sharp, staining red with eosin. In the center there 
was dense connective tissue and many blood vessels had very 
thick walls. 
Follicles of small, medium and large size, with well preserved 
granulosa, were present. A few mature, red staining follicles with- 
out mitoses or degeneration in the granulosa were also found. 
Many other large immature follicles showed various stages of 
granulosa degeneration. There were of course also present 
various stages of connective tissue atresia. 
We see therefore that abortion is not followed by or associated 
with marked changes in the follicles. Whether the mature follicles 
which we found in these ovaries matured as a result of abortion, or 
whether the mature follicles were present before the onset of abor- 
tion, we cannot state with certainty, although it is more probable 
that maturation of the follicles followed abortion. We also note 
the beginning retrogressive changes in the corpora lutea. But in 
this case also we cannot be sure that the degenerative processes 
had not set in before the abortion had commenced. 
OVARIES OF GUINEA PIGS FOUR TO SEVEN AND ONE HALF DAYS 
AFTER OVULATION 
Six days after an ovulation we find in the ovaries on the whole 
the following condition of the follicles: There are well preserved 
follicles of small and medium size, with mitoses in the granulosa 
cells. A limited amount of granulosa degeneration is found only 
in rare instances. In such follicles mitoses are absent or their 
