16 MATHILDE M. LANGE 
animals are also closed by the agglutination of the leucocytes, 
but the agglutination is accompanied by blood coagulation, as 
the blood of the Arthropoda contains fibrinogen. The leucocytes 
of the Cephalopoda do not undergo any great change during 
agglutination. I could not observe any formation of pseudopods 
such as Loeb (’09) and Geddes (’01) describe. The only alter- 
ation which I could discover in the blood-corpuscles was hyalino- 
sis resulting from the disappearance of a great number of granules. 
The change wrought by hyalinosis can be plainly seen in com- 
paring figures 4 and 19. The blood-plasm seems to disappear 
soon after the bleeding stops, for I could not find any trace of 
it on most of the sections. Were it not for a few cases such as 
one exhibited in figures 19 and 22, where blood plasm is still 
present, one could easily suspect that the plasm flows away 
immediately after leaving the blood-vessels. If we examine 
the plasm in the blood-clou closely, we can detect a difference 
between it and the plasm in the blood-vessels. In the first place, 
the plasm of the clot is not as uniform in structure as the plasm 
in the blood-vessels, and, secondly, it does not stain the same 
intense brown-red, when the combined stain of Heidenhain and 
eosin is employed. But in spite of these differences, it still 
retains the character of blood-plasm. In some sections made 
of pieces which had been fixed after a period of five hours after 
operation, I even found the plasm of the blood-clot almost 
identically the same in appearance as the plasm in the blood- 
vessels. Gradually the blood-plasm entirely disappears from 
the cicatricial tissue. As no signs of degeneration were visible, 
the plasm probably becomes absorbed, but unfortunately, I 
was not able to find out how this is done. After the disappear- 
ance of the blood-plasm the cicatricial tissue looks like a very 
close network of thin threads, in which numerous nuclei are 
embedded (figs. 20 and 21). The fact that these nuclei increase 
in numbers would indicate that they multiply. Migration of 
nuclei from the subjacent tissue is not likely, for the cicatricial 
tissue is separated from all tissues, with the exception of the 
musculature, by a very distinct boundary line. The muscles, 
however, being in a state of degeneration, which-begins before 
