AUTHORS’ ABSTRACT OF THIS PAPER ISSUED 
BY THE BIBLIOGRAPHIC SERVICH, JULY 26 
STUDIES ON CYTOLYSINS 
II. TRANSMISSION OF INDUCED EYE-DEFECTS 
M. F. GUYER AND E. A. SMITH 
Zoological Laboratory, University of Wisconsin 
SEVEN FIGURES AND FOUR PLATES 
INTRODUCTION 
In a former paper (Guyer and Smith, 718) we recorded the 
results obtained during the year 1916-17 from experiments in 
which pregnant rabbits and pregnant mice were treated with 
fowl serum sensitized, respectively, to the crystalline lens of the 
rabbit and of the mouse. It was found that antenatal defects in 
the lenses of the young could be secured in this way. Thus, 
in rabbits treated during pregnancy with fowl serum sensitized 
to rabbit lens, some of the young showed eye defects, such as 
opacity of the lens and partial or, less frequently, complete lique- 
faction of the lens. Similar results were obtained with mice of 
the genus Peromyscus. 
The present paper deals with the continuation and repetition 
of these experiments in rabbits, and includes an account of the 
transmission through successive generations of eye defects orig- 
inally induced by means of lens-sensitized fowl serum. To do 
away with the possibility of accident or coincidence, it was 
obviously desirable to secure other well-established cases This 
is particularly true for the genetical aspects of the experiments. 
Since, in our opinion, the fact of transmissiblity is by far the 
most significant one established, in repeating the original experi- 
ment we have taken pains to secure wholly unrelated stock so 
that we may be sure that we are not simply perpetuating a 
chance inheritable defect which has sprung up by some strange 
coincidence just at the time of our work. To safeguard the 
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