TRANSMISSION OF INDUCED EYE-DEFECTS 187 
young were born. One of these died two days later. Two of 
the remaining four had eyes normal in appearance and two had 
eyes markedly abnormal (fig. 3). One of the normal-eyed ones 
died when about three months old. 
TABLE 6 
Experiment 22 
I. Sensitization of fowls 
NUMBER OF RAB- NORMAL SALT DOSAGE PER 
paTE—1919 FOWLS REINJECTED! 507 LENSES USED SOLUTION FOWL 
ce. ce. 
June 12 2, 4 12 3 
June 14 2 4 12 3 
June 20 2 4 12 5 
II. Treatment of rabbit 
IDENTIFI- 
ROECHION ieasons are Gare Sao ES 
OF RABBITS 
~ cc. 
June 28| 16A1 8 4 Five young born July 21. 1 soon died; 
June 30| 16A1 10 4 2 had very defctive eyes; 2 had nor- 
July 5 16Al1 15 4 mal eyes 
July 7 16A1 17 4 16A1 2 was mated to 50 & 
CONTROLS 
To determine whether eye defects induced by lens-sensitized 
fowl serum as just described are attributable to the specific action 
of the antibodies or merely to a general poisonous or asthenic 
-effect of the fowl serum, it is obvious that careful controls must 
be instituted. Before the effect can be pronounced specific, it 
is also necessary to establish the fact that fowl serum sensitized 
to other tissues of the rabbit than crystalline lens will not induce 
the lens defects in question. To secure such controls we in- 
jected a number of pregnant does with pure (that is, unsensi- 
sitized) fowl serum, and still others with fowl serum which had 
been sensitized to rabbit testis. The experiments follow. 
