194 M. F. GUYER AND E. A. SMITH 
determine, as the matter seemed to have little or no direct bear- 
ing upon the experiments in hand, but it is a fact that the rab-. 
bits showed more symptoms of illness after injection with such 
serum than with the serum used in earlier experiments, and in 
one instance, in a later set of controls, one rabbit died in convul-. 
sions about four hours after being injected. On the other hand, 
more of the does finally bore young than in any other set of 
experiments. 
The details of dosage, number of injections, dates, ete., are set 
forth in table 13. A total of twenty-eight young were obtained 
from the four does under treatment. Two of the young died 
before their eyes were open, leaving twenty-six to be examined 
for eye defects. The entire twenty-six were found to have nor- 
mal eyes. 
Experiment 24 
Three fowls and four rabbits were used as shown in table 14. 
The fowls were each given 5 cc. of an emulsion of pulped rabbit 
testis in normal saline solution on five different occasions at in- 
tervals of about a week. Three of the rabbits received five injec- 
tions of the testis-sensitized serum, one of them only four. The 
latter, no. 16A1, died in convulsions about four hours after the 
fourth injection, having been pregnant twenty days. An au- 
topsy showed that she was carrying eight young. No. 17 bore 
seven young, all normal-eyed; no. 36, three young, all normal- 
eyed. No. 37 bore three young, but as she had made no nest 
and did not care for them in any way, they died. Thus the ex- 
periment yielded ten young which survived, all with normal 
eyes. 
IS THE REACTION SPECIFIC? 
Before entering upon the question of specificity, it seems ad- 
visible to say a word further about the nature of the defects. In 
our opinion, practically all of the eye defects obtained, both in the 
immediate young of treated mothers and in subsequent genera- 
tions, are of such a nature that they may reasonably be inter- 
preted as due primarily to suppressed or abnormal development. 
