TRANSMISSION OF INDUCED EYE-DEFECTS 203 
show the defects or, in other words, that normality is not always 
dominant. Such ‘reversed’ dominance, however, is by no means 
unknown in the annals of Mendelism. We are entering upon a 
series of matings to clear up this and other doubtful points con- 
nected with the exact mode of inheritance. 
For starting our investigation into the inheritance of the de- 
fect, the offspring of a female designated in our pedigree charts 
as no. | and a male, no. 2, were selected (fig. 5). This pair had 
already yielded a normal litter of five before they were used in 
the serum work. After being mated to no. 2, November 30, 1916, 
39 JA/ 
J2EI B2B2 32B3 32BY SLB5 3ZAI RAZ 3B2A3 32A4 3LAS 32 AG 
Ms A A 
46Al 4OAR HAS 4644 YOA5S 46A6 4OAT 
Fig. 7 Inheritance of the defect through the male line. Symbols same as 
in figure 5. 
the female had been injected with fowl serum sensitized with rab- 
bit lens. The details of this sensitization and the schedule of 
injections are given in our 1918 paper, page 73, table 2, in which 
this same female is designated as rabbit B. In the ensuing litter, 
born December 30, was a male with a markedly defective left 
eye which in time almost entirely disappeared. In order to find 
out whether or not this defect could be transmitted to the next 
generation, this male, numbered 3A1, was mated to his sister 
3A2, whose eyes were normal as far as could be ascertained from 
an external examination (fig. 5). The offspring, known as the 4A 
series, born November, 1917, showed surprising results, for three 
females from the litter of eight young had abnormal eyes. In 
